Anti-Extracellular matrix protein 1 抗体 [SPM217] (ab17921)

製品の概要

  • 製品名Anti-Extracellular matrix protein 1 antibody [SPM217]
    Extracellular matrix protein 1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [SPM217] to Extracellular matrix protein 1
  • 特異性ab17921 reacts with a reduction-resistant epitope present in both free and SIgA bound Secretory Component. It does not react with the cell lines lacking secretory component. The antibody is useful for studying the distribution and level of both free and bound secretory component. Secretory component is differentially expressed in epithelium, and the antibody is a popular marker for identifying subpopulations of epithelial cells and epithelial differentiation. The Secretory component antibody is a useful research tool for studying mucosal immunity, inflammation, remodeling, differentiation and tumorigenesis, all processes associated with differential secretory component expression.
  • アプリケーション適用あり: ICC/IF, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rat
  • 免疫原

    Full length native protein (purified) corresponding to Human Secretory Component Glycoprotein. Secretory Component protein isolated from human colostrum.

  • エピトープNot determined
  • ポジティブ・コントロール
    • Stomach, Lung, or breast tumor.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab17921 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 1 - 2 µg/ml.
IHC-P 1/50. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.

ターゲット情報

  • 機能Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
  • 組織特異性Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.
  • 関連疾患Defects in ECM1 are the cause of lipoid proteinosis (LiP) [MIM:247100]; also known as lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.
  • 細胞内局在Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ECM 1 antibody
    • Ecm1 antibody
    • ECM1_HUMAN antibody
    • Extracellular matrix protein 1 antibody
    • Secretory component p85 antibody
    • URBWD antibody
    see all

Anti-Extracellular matrix protein 1 antibody [SPM217] 画像

  • Human colon carcinoma stained with ab17921.

Anti-Extracellular matrix protein 1 antibody [SPM217] (ab17921) 使用論文

ab17921 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"