Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.
Glycan metabolism; heparan sulfate biosynthesis.
Belongs to the glycosyltransferase 47 family.
The soluble form derives from the membrane form by proteolytic processing.
Endoplasmic reticulum membrane and Secreted. A soluble form is found in the serum.