製品の概要

  • 製品名Anti-Ext2 antibody
    Ext2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to Ext2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Recombinant Fragment
    交差が予測される動物種: Human
  • 免疫原

    Recombinant fragment: GFSTWTYRQG YDVSIPVYSP LSAEVDLPEK GPGPRQYFLL SSQVGLHPEY REDLEALQVK HGESVLVLDK CTNLSEGVLS VRKRCHKHQV FDYPQVLQEA , corresponding to amino acids 216-315 of Human Ext2

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • アイソタイプIgG1
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab54711 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor.
    • 組織特異性Ubiquitous.
    • パスウェイProtein modification; protein glycosylation.
    • 関連疾患Defects in EXT2 are a cause of hereditary multiple exostoses type 2 (EXT2) [MIM:133701]. EXT is a genetically heterogeneous bone disorder caused by genes segregating on human chromosomes 8, 11, and 19 and designated EXT1, EXT2 and EXT3 respectively. EXT is a dominantly inherited skeletal disorder primarily affecting endochondral bone during growth. The disease is characterized by formation of numerous cartilage-capped, benign bone tumors (osteocartilaginous exostoses or osteochondromas) that are often accompanied by skeletal deformities and short stature. In a small percentage of cases exostoses have exhibited malignant transformation resulting in an osteosarcoma or chondrosarcoma. Osteochondromas development can also occur as a sporadic event.
      Defects in EXT2 are the cause of Potocki-Shaffer syndrome (PSS) [MIM:601224]. It is a contiguous gene syndrome due to proximal deletion of chromosome 11p11.2, including EXT2 and ALX4.
    • 配列類似性Belongs to the glycosyltransferase 47 family.
    • 細胞内局在Endoplasmic reticulum membrane. Golgi apparatus membrane. The EXT1/EXT2 complex is localized in the Golgi apparatus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Exostoses (multiple) 2 antibody
      • Exostosin 2 antibody
      • Exostosin-2 antibody
      • EXT2 antibody
      • EXT2_HUMAN antibody
      • Glucuronosyl N acetylglucosaminyl proteoglycan 4 alpha N acetylglucosaminyltransferase antibody
      • Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase antibody
      • Multiple exostoses protein 2 antibody
      • N acetylglucosaminyl proteoglycan 4 beta glucuronosyltransferase antibody
      • Putative tumor suppressor protein EXT2 antibody
      • SOTV antibody
      see all

    Anti-Ext2 antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab54711 Ext2 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa.

      This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Anti-Ext2 antibody (ab54711) 使用論文

    ab54711 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab54711.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"