Anti-Exosome Component 9 抗体 [2337C3a] (ab54283)


  • 製品名Anti-Exosome Component 9 antibody [2337C3a]
    Exosome Component 9 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [2337C3a] to Exosome Component 9
  • アプリケーション適用あり: Dot Blot, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Exosome component 9 recombinant fragment (Human)


  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファーPreservative: 0.05% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 精製度Protein G purified
  • 特記事項(精製)ab54283 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. Filtered through a 0.22 µm membrane.
  • ポリ/モノモノクローナル
  • クローン名2337C3a
  • アイソタイプIgG1
  • 研究分野


Our Abpromise guarantee covers the use of ab54283 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Dot Blot Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 49 kDa.


  • 機能Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as anti-sense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs.
  • 配列類似性Belongs to the RNase PH family.
  • 細胞内局在Nucleus > nucleolus; Cytoplasm. Nucleus > nucleolus and Nucleus. Excluded from the nucleolus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Autoantigen PM/Scl 1 antibody
    • EXOS9_HUMAN antibody
    • EXOSC 9 antibody
    • EXOSC9 antibody
    • Exosome complex component RRP45 antibody
    • Exosome complex exonuclease RRP45 antibody
    • Exosome component 9 antibody
    • p5 antibody
    • p6 antibody
    • P75 polymyositis scleroderma overlap syndrome associated autoantigen antibody
    • P75 polymyositis-scleroderma overlap syndrome-associated autoantigen antibody
    • PM/Scl 75 antibody
    • PM/Scl-75 antibody
    • PMSCL autoantigen 75kD antibody
    • PMSCL1 antibody
    • Polymyositis/scleroderma autoantigen 1 75kDa antibody
    • Polymyositis/scleroderma autoantigen 1 antibody
    • Polymyositis/scleroderma autoantigen 75 kDa antibody
    • RRP45 antibody
    • Rrp45p antibody
    see all

Anti-Exosome Component 9 antibody [2337C3a] 画像

Anti-Exosome Component 9 antibody [2337C3a] (ab54283) 使用論文

ab54283 has not yet been referenced specifically in any publications.

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