製品の概要

  • 製品名Anti-EXOSC7 antibody
    EXOSC7 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to EXOSC7
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1 - 291 of Human EXOSC7 (NP_055819.1)

  • ポジティブ・コントロール
    • WB: Jurkat cell lysate; ICC/IF: HeLa cells.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein A purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab89104 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 32 kDa.
ICC/IF Use a concentration of 10 µg/ml.

ターゲット情報

  • 機能Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as anti-sense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
  • 配列類似性Belongs to the RNase PH family.
  • 細胞内局在Nucleus > nucleolus. Cytoplasm. Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • EAP1 antibody
    • EXOS7_HUMAN antibody
    • Exosc7 antibody
    • Exosome complex component RRP42 antibody
    • Exosome complex exonuclease RRP42 antibody
    • Exosome component 7 antibody
    • FLJ26543 antibody
    • hRrp42p antibody
    • KIAA0116 antibody
    • p8 antibody
    • Ribosomal RNA processing protein 42 antibody
    • Ribosomal RNA-processing protein 42 antibody
    • RRP42 antibody
    • Rrp42p antibody
    see all

Anti-EXOSC7 antibody 画像

  • Anti-EXOSC7 antibody (ab89104) at 1 µg/ml + Jurkat cell lysate at 50 µg

    Predicted band size : 32 kDa
  • All lanes : Anti-EXOSC7 antibody (ab89104) at 1 µg/ml

    Lane 1 : EXOSC7-transfected 293T cell lysate
    Lane 2 : non transfected lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 32 kDa
    Observed band size : 32 kDa
  • Analysis of EXOSC7 expression in PFA-fixed, permeabilized HeLa cells using ab89104 at 10 µg/ml, followed by a fluorescein-conjugated secondary antibody.

Anti-EXOSC7 antibody (ab89104) 使用論文

ab89104 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"