Anti-EXOC7 抗体 (ab95981)
Key features and details
- Rabbit polyclonal to EXOC7
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-EXOC7 antibody
EXOC7 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to EXOC7 -
由来種
Rabbit -
アプリケーション
適用あり: WB, ICC/IFmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse -
免疫原
Recombinant protein fragment containing a sequence corresponding to a region within amino acids 74 and 345 of EXOC7 (NP_001013861; UniProt ID: Q9UPT5 isoform 1).
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ポジティブ・コントロール
- WB: HeLa whole cell lysate; H1299, HepG2 and MOLT4 cell lysates ICC/IF: A431 cell
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab95981の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 78 kDa.
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ICC/IF |
1/100 - 1/200.
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特記事項 |
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WB
1/500 - 1/3000. Predicted molecular weight: 78 kDa. |
ICC/IF
1/100 - 1/200. |
ターゲット情報
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機能
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion. -
配列類似性
Belongs to the EXO70 family. -
ドメイン
The N-terminus is involved in SEC8 and ARHQ binding.
The C-terminus is required for translocation to the plasma membrane. -
細胞内局在
Cytoplasm > cytosol. Cell membrane. Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ. - Information by UniProt
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参照データベース
- Entrez Gene: 23265 Human
- Entrez Gene: 53413 Mouse
- Omim: 608163 Human
- SwissProt: Q9UPT5 Human
- SwissProt: O35250 Mouse
- Unigene: 514496 Human
- Unigene: 22530 Mouse
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別名
- 2 5 3p antibody
- DKFZp686J04253 antibody
- EX070 antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab95981 は 3 報の論文で使用されています。
- Ulloa R et al. B Cells Adapt Their Nuclear Morphology to Organize the Immune Synapse and Facilitate Antigen Extraction. Front Immunol 12:801164 (2021). PubMed: 35222354
- Sáez JJ et al. The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells. J Cell Biol 218:2247-2264 (2019). PubMed: 31197029
- Arasaki K et al. Legionella remodels the plasma membrane-derived vacuole by utilizing exocyst components as tethers. J Cell Biol 217:3863-3872 (2018). PubMed: 30275106