製品の概要

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab23465 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration.
WB Use a concentration of 1 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 50 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA 1/375000.

ターゲット情報

  • 機能Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'.
  • 組織特異性Ubiquitous.
  • 関連疾患Note=A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).
    Note=Chromosomal aberrations involving ETV6 are found in a form of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with MN1; translocation t(4;12)(q12;p13) with CHIC2.
    Note=Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL). Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1.
    Note=A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation t(9;12)(p24;p13) with JAK2.
    Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS) with basophilia. Translocation t(5;12)(q31;p13) with ACSL6.
    Note=A chromosomal aberration involving ETV6 is found in acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ACSL6.
    Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2.
    Defects in ETV6 are a cause of myeloproliferative disorder chronic with eosinophilia (MPE) [MIM:131440]. A hematologic disorder characterized by malignant eosinophils proliferation. Note=A chromosomal aberration involving ETV6 is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein.
    Defects in ETV6 are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development.
    Note=A chromosomal aberration involving ETV6 is found in acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5.
  • 配列類似性Belongs to the ETS family.
    Contains 1 ETS DNA-binding domain.
    Contains 1 PNT (pointed) domain.
  • 翻訳後修飾Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ETS related protein Tel1 antibody
    • ETS translocation variant 6 antibody
    • Ets variant 6 antibody
    • Ets variant gene 6 (TEL oncogene) antibody
    • ETS-related protein Tel1 antibody
    • ETV 6 antibody
    • ETV6 antibody
    • ETV6_HUMAN antibody
    • Tel antibody
    • TEL oncogene antibody
    • TEL/ABL antibody
    • TEL1 antibody
    • TEL1 oncogene antibody
    • Transcription factor ETV 6 antibody
    • Transcription factor ETV6 antibody
    see all

Anti-ETV6 / Tel antibody 画像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human stomach tissue labelling ETV6 / Tel at 4µg/ml. The arrows indicate epithelial cells of fundic glands staining positively.

Anti-ETV6 / Tel antibody (ab23465) 使用論文

This product has been referenced in:
  • Diakos C  et al. TEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320a. Blood 116:4885-93 (2010). WB ; Human . Read more (PubMed: 20807887) »

See 1 Publication for this product

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I have conducted a search for you at our website and found 5 antibodies against ETV6 / Tel:

ab23465,

ab54705,

ab64909,

ab74361,

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No. This antibody recognizes the C-terminal portion of TEL.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"