Anti-ETV6 / Tel 抗体 (ab123445)

製品の概要

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab123445 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 53 kDa.

ターゲット情報

  • 機能Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'.
  • 組織特異性Ubiquitous.
  • 関連疾患Note=A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).
    Note=Chromosomal aberrations involving ETV6 are found in a form of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with MN1; translocation t(4;12)(q12;p13) with CHIC2.
    Note=Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL). Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1.
    Note=A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation t(9;12)(p24;p13) with JAK2.
    Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS) with basophilia. Translocation t(5;12)(q31;p13) with ACSL6.
    Note=A chromosomal aberration involving ETV6 is found in acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ACSL6.
    Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2.
    Defects in ETV6 are a cause of myeloproliferative disorder chronic with eosinophilia (MPE) [MIM:131440]. A hematologic disorder characterized by malignant eosinophils proliferation. Note=A chromosomal aberration involving ETV6 is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein.
    Defects in ETV6 are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development.
    Note=A chromosomal aberration involving ETV6 is found in acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5.
  • 配列類似性Belongs to the ETS family.
    Contains 1 ETS DNA-binding domain.
    Contains 1 PNT (pointed) domain.
  • 翻訳後修飾Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ETS related protein Tel1 antibody
    • ETS translocation variant 6 antibody
    • Ets variant 6 antibody
    • Ets variant gene 6 (TEL oncogene) antibody
    • ETS-related protein Tel1 antibody
    • ETV 6 antibody
    • ETV6 antibody
    • ETV6_HUMAN antibody
    • Tel antibody
    • TEL oncogene antibody
    • TEL/ABL antibody
    • TEL1 antibody
    • TEL1 oncogene antibody
    • Transcription factor ETV 6 antibody
    • Transcription factor ETV6 antibody
    see all

Anti-ETV6 / Tel antibody 画像

  • Anti-ETV6 / Tel antibody (ab123445) at 1/100 dilution + Mouse lung tissue lysate

    Predicted band size : 53 kDa

Anti-ETV6 / Tel antibody (ab123445) 使用論文

ab123445 has not yet been referenced specifically in any publications.

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