Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism.
Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity. Sumoylated by SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activiy, but has no effect on subcellular location nor on DNA binding.
ab93173, at a 1/50 dilution, staining Estrogen Related Receptor alpha in formalin-fixed and paraffin-embedded Human kidney carcinoma, peroxidase-conjugated to a FITC-conjugated goat-anti-rabbit secondary antibody, followed by DAB staining.
Flow Cytometry - Estrogen Related Receptor alpha antibody (ab93173)
ab93173, at a 1/10 dilution, staining Estrogen Related Receptor alpha in 293 cells by flow cytometric analysis (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibody used for analysis.