Anti-Estrogen Receptor beta (phospho S105) 抗体 (ab62257)


  • 製品名Anti-Estrogen Receptor beta (phospho S105) antibody
    Estrogen Receptor beta 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Estrogen Receptor beta (phospho S105)
  • 特異性ab62257 detects endogenous levels of Estrogen Receptor beta only when phosphorylated at serine 105.
  • アプリケーション適用あり: IHC-P, WB, ELISA, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic phosphopeptide derived from human Estrogen Receptor beta around the phosphorylation site of serine 105 (Q-K-SP-P-W).

  • ポジティブ・コントロール
    • HuvEc cells.



Our Abpromise guarantee covers the use of ab62257 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration. PubMed: 20696772
WB Use at an assay dependent concentration. PubMed: 20696772
ELISA 1/5000.
ICC/IF 1/500 - 1/1000.


  • 機能Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
  • 組織特異性Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.
  • 配列類似性Belongs to the nuclear hormone receptor family. NR3 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • ドメインComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ER BETA antibody
    • ER-beta antibody
    • Erb antibody
    • ESR B antibody
    • ESR BETA antibody
    • ESR2 antibody
    • ESR2_HUMAN antibody
    • ESRB antibody
    • ESTRB antibody
    • estrogen nuclear receptor beta variant a antibody
    • estrogen nuclear receptor beta variant b antibody
    • estrogen receptor 2 (ER beta) antibody
    • Estrogen receptor 2 antibody
    • estrogen receptor beta 4 antibody
    • Estrogen receptor beta antibody
    • NR3A2 antibody
    • Nuclear receptor subfamily 3 group A member 2 antibody
    see all

Anti-Estrogen Receptor beta (phospho S105) antibody 画像

  • ab62257 at 1/500 - 1/1000 dilution staining Estrogen Receptor beta in HuvEc cells by Immunofluorescence, in the absence or presence of the immunising peptide

Anti-Estrogen Receptor beta (phospho S105) antibody (ab62257) 使用論文

This product has been referenced in:
  • Hamilton-Burke W  et al. Phosphorylation of Estrogen Receptor {beta} at Serine 105 Is Associated with Good Prognosis in Breast Cancer. Am J Pathol 177:1079-86 (2010). WB, IHC-P ; Human . Read more (PubMed: 20696772) »

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