Anti-Estrogen Receptor alpha (phospho S104 + S106) 抗体 (ab51107)

製品の概要

  • 製品名Anti-Estrogen Receptor alpha (phospho S104 + S106) antibody
    Estrogen Receptor alpha 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Estrogen Receptor alpha (phospho S104 + S106)
  • 特異性ab51107 detects endogenous levels of Estrogen Receptor alpha only when phosphorylated at serine 104/106.
  • アプリケーション適用あり: IHC-P, WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    A synthetic phospho-peptide derived from human Estrogen Receptor alpha around the phosphorylation site of serine 104/106 (V-SP-P-SP-P).

  • ポジティブ・コントロール
    • IHC-P: Human breast carcinoma tissue; WB: Estradiol- treated MCF7 cell lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab51107 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
WB
ELISA
  • 追加情報ELISA: 1/10000.
    IHC-P: 1/50 - 1/100.
    WB: 1/500 - 1/1000. Predicted molecular weight (non-phosphorilated protein): 65 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1.
    • 配列類似性Belongs to the nuclear hormone receptor family. NR3 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • ドメインComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
    • 翻訳後修飾Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.
      Glycosylated; contains N-acetylglucosamine, probably O-linked.
      Ubiquitinated. Deubiquitinated by OTUB1.
      Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization.
      Palmitoylated (isoform 3). Not biotinylated (isoform 3).
    • 細胞内局在Nucleus. Cytoplasm. Cell membrane. A minor fraction is associated with the inner membrane and Nucleus. Cytoplasm. Cell membrane. Associated with the inner membrane via palmitoylation.
    • Information by UniProt
    • 参照データベース
    • 別名
      • DKFZp686N23123 antibody
      • ER alpha antibody
      • ER antibody
      • ER-alpha antibody
      • Era antibody
      • ESR antibody
      • ESR1 antibody
      • ESR1_HUMAN antibody
      • ESRA antibody
      • Estradiol receptor antibody
      • Estrogen nuclear receptor alpha antibody
      • Estrogen receptor 1 antibody
      • Estrogen receptor alpha 3*,4,5,6,7*/822 isoform antibody
      • Estrogen receptor alpha antibody
      • Estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform antibody
      • Estrogen receptor alpha delta 3*,4,5,6,7*/819 2 isoform antibody
      • Estrogen receptor alpha delta 4 +49 isoform antibody
      • Estrogen receptor alpha delta 4*,5,6,7*/654 isoform antibody
      • Estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform antibody
      • Estrogen receptor alpha E1 E2 1 2 antibody
      • Estrogen receptor alpha E1 N2 E2 1 2 antibody
      • Estrogen receptor antibody
      • ESTRR antibody
      • NR3A1 antibody
      • Nuclear receptor subfamily 3 group A member 1 antibody
      see all

    Anti-Estrogen Receptor alpha (phospho S104 + S106) antibody 画像

    • All lanes : Anti-Estrogen Receptor alpha (phospho S104 + S106) antibody (ab51107)

      Lane 1 : Untreated MCF7 cell lysate.
      Lane 2 : Estradiol-treated MCF7 cell lysate.


      Predicted band size : 65 kDa
    • ab51107 (1/100) staining Estrogen Receptor alpha (phospho S104 + S106) in paraffin embedded human breast carcinoma tissue by Immunohistochemistry. Right panel represents a negative control experiment done in the presence of the immunizing (blocking) phospho-peptide.

    Anti-Estrogen Receptor alpha (phospho S104 + S106) antibody (ab51107) 使用論文

    ab51107 has not yet been referenced specifically in any publications.

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