Anti-Estrogen Receptor alpha (phospho S102) 抗体 (ab111917)

製品の概要

  • 製品名Anti-Estrogen Receptor alpha (phospho S102) antibody
    Estrogen Receptor alpha 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Estrogen Receptor alpha (phospho S102)
  • 特異性ab111917 detects endogenous levels of Estrogen Receptor alpha only when phosphorylated at serine 102.
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to Human Estrogen Receptor alpha aa 71-120. Synthetic phosphopeptide derived from Human Estrogen Receptor alpha around the phosphorylation site of serine 102 (L-N-SP-V-S).
    Database link: P03372

  • ポジティブ・コントロール
    • Human Breast carcinoma tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111917 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1.
  • 配列類似性Belongs to the nuclear hormone receptor family. NR3 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • ドメインComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 翻訳後修飾Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.
    Glycosylated; contains N-acetylglucosamine, probably O-linked.
    Ubiquitinated. Deubiquitinated by OTUB1.
    Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization.
    Palmitoylated (isoform 3). Not biotinylated (isoform 3).
  • 細胞内局在Nucleus. Cytoplasm. Cell membrane. A minor fraction is associated with the inner membrane and Nucleus. Cytoplasm. Cell membrane. Associated with the inner membrane via palmitoylation.
  • Information by UniProt
  • 参照データベース
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Anti-Estrogen Receptor alpha (phospho S102) antibody 画像

  • ab111917 at 1/50 dilution staining Estrogen Receptor alpha in paraffin-embedded Human Breast carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-Estrogen Receptor alpha (phospho S102) antibody (ab111917) 使用論文

ab111917 has not yet been referenced specifically in any publications.

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