製品の概要

  • 製品名Anti-ESE1 antibody
    ESE1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ESE1
  • 特異性This antibody recognizes human ESE-1 (39-41 kD).
  • アプリケーション適用あり: ICC/IF, ELISA, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    N-terminal sequence MAATCEISNIFSNYFS and C-terminal sequence SSGWKEEEVLQSRN of human ESE-1 protein.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPBS with 0.02% sodium azide
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab1392 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use at an assay dependent dilution.
ELISA 1/500 - 1/1100.
WB 1/1000 - 1/5000. Predicted molecular weight: 41 kDa.

ターゲット情報

  • 機能Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
  • 組織特異性Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.
  • 配列類似性Belongs to the ETS family.
    Contains 1 ETS DNA-binding domain.
    Contains 1 PNT (pointed) domain.
  • ドメインthe 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • 細胞内局在Cytoplasm. Nucleus. Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism.
  • Information by UniProt
  • 参照データベース
  • 別名
    • E74 like factor 3 antibody
    • E74 like factor 3 ets domain transcription factor antibody
    • E74 like factor 3 ets domain transcription factor epithelial specific antibody
    • E74 like factor 3 ETS domain transcription factor serine box epithelial specific antibody
    • E74-like factor 3 antibody
    • Elf3 antibody
    • ELF3_HUMAN antibody
    • Epithelial restricted with serine box antibody
    • Epithelial-restricted with serine box antibody
    • Epithelium restricted Ets protein ESX antibody
    • Epithelium specific Ets factor 1 antibody
    • Epithelium specific Ets transcription factor 1 antibody
    • Epithelium-restricted Ets protein ESX antibody
    • Epithelium-specific Ets transcription factor 1 antibody
    • EPR 1 antibody
    • EPR1 antibody
    • ERT antibody
    • ESE-1 antibody
    • ESX antibody
    • Ets domain transcription factor serine box antibody
    • Ets domain transcription factor serine box epithelial specific antibody
    • Ets transcription factor antibody
    • ETS-related transcription factor Elf-3 antibody
    • jen antibody
    • MGC139318 antibody
    see all

Anti-ESE1 antibody (ab1392) 使用論文

This product has been referenced in:
  • Longoni N  et al. ETS transcription factor ESE1/ELF3 orchestrates a positive feedback loop that constitutively activates NF-?B and drives prostate cancer progression. Cancer Res 73:4533-47 (2013). Read more (PubMed: 23687337) »
  • Manavathi B  et al. Phosphorylation-dependent regulation of stability and transforming potential of ETS transcriptional factor ESE-1 by p21-activated kinase 1. J Biol Chem 282:19820-30 (2007). WB, ICC/IF ; Human . Read more (PubMed: 17491012) »

See all 2 Publications for this product

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Thank you for your reply. We are sorry to hear that you are still having difficulty with this antibody. Unfortunately, we do not have another lot of this antibody to offer. We sell a fair amount of this product, so we checked with a few customers w...

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Thank you for your enquiry and for taking your time to fill in the on-line Questionnaire. We are very sorry to hear that you are having problem with this antibody. Although we have not evaluated this antibody on Caco-2 cell extracts, we have used T8...

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