製品の概要

  • 製品名Anti-ERCC8 antibody
    ERCC8 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ERCC8
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    KLH conjugated synthetic peptide between internal sequence amino acids 210-238 of Human ERCC8 (NP_000073.1).

  • ポジティブ・コントロール
    • Mouse spleen tissue lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab107290 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 44 kDa.

ターゲット情報

  • 機能Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitement of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.
  • パスウェイProtein modification; protein ubiquitination.
  • 関連疾患Defects in ERCC8 are the cause of Cockayne syndrome type A (CSA) [MIM:216400]. Cockayne syndrome is a rare disorder characterized by cutaneous sensitivity to sunlight, abnormal and slow growth, cachectic dwarfism, progeroid appearance, progressive pigmentary retinopathy and sensorineural deafness. There is delayed neural development and severe progressive neurologic degeneration resulting in mental retardation. Two clinical forms are recognized: in the classical form or Cockayne syndrome type 1, the symptoms are progressive and typically become apparent within the first few years or life; the less common Cockayne syndrome type 2 is characterized by more severe symptoms that manifest prenatally. Cockayne syndrome shows some overlap with certain forms of xeroderma pigmentosum. Unlike xeroderma pigmentosum, patients with Cockayne syndrome do not manifest increased freckling and other pigmentation abnormalities in the skin and have no significant increase in skin cancer.
  • 配列類似性Contains 5 WD repeats.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CKN1 antibody
    • Cockayne syndrome type A antibody
    • Cockayne syndrome WD repeat protein CSA antibody
    • CSA antibody
    • DNA excision repair protein ERCC-8 antibody
    • DNA excision repair protein ERCC8 antibody
    • ERCC 8 antibody
    • ERCC8 antibody
    • ERCC8_HUMAN antibody
    • excision repair cross-complementing rodent repair deficiency, complementation group 8 antibody
    see all

Anti-ERCC8 antibody 画像

  • Anti-ERCC8 antibody (ab107290) at 1/100 dilution + Mouse spleen tissue lysate at 35 µg

    Predicted band size : 44 kDa

Anti-ERCC8 antibody (ab107290) 使用論文

ab107290 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"