Anti-ERCC1 抗体 [EP2143Y] (ab76236)

製品の概要

• 製品名
  Anti-ERCC1 antibody [EP2143Y]
  ERCC1 一次抗体 製品一覧
• 製品の詳細
  Rabbit monoclonal [EP2143Y] to ERCC1
• 特異性
  ab76236 might also detect a heterodimer composed of ERCC1 and XPF/ERCC4 at 100-150 kDa.
• アプリケーション
  適用あり: WB, Flow Cytmore details
  適用なし: ICC,IHC-P or IP
• 種交差性
  交差種: Human
  
• 免疫原

  Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to Human ERCC1 aa 1-100 (N terminal).

• ポジティブ･コントロール
  • SKBR-3 cell lysate
• 特記事項

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

  Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• バッファー
  PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• 精製度
  Tissue culture supernatant
• ポリ/モノ
  モノクローナル
• クローン名
  EP2143Y
• アイソタイプ
  IgG
• 研究分野
  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • Nucl. Excision Repair

  • Cancer
  • Tumor biomarkers
  • Other

アプリケーション

ターゲット情報

• 機能
  Structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair.
• 関連疾患
  Defects in ERCC1 are the cause of cerebro-oculo-facio-skeletal syndrome type 4 (COFS4) [MIM:610758]. COFS is a degenerative autosomal recessive disorder of prenatal onset affecting the brain, eye and spinal cord. After birth, it leads to brain atrophy, hypoplasia of the corpus callosum, hypotonia, cataracts, microcornea, optic atrophy, progressive joint contractures and growth failure. Facial dysmorphism is a constant feature. Abnormalities of the skull, eyes, limbs, heart and kidney also occur.
• 配列類似性
  Belongs to the ERCC1/RAD10/SWI10 family.
• 細胞内局在
  Nucleus.

• Target information above from: UniProt accession P07992 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 2067 Human
  • Omim: 126380 Human
  • SwissProt: P07992 Human
  • Unigene: 435981 Human
• 別名
  • COFS 4 antibody
  • COFS4 antibody
  • DNA excision repair protein ERCC 1 antibody

  • DNA excision repair protein ERCC-1 antibody
  • DNA excision repair protein ERCC1 antibody
  • ERCC 1 antibody
  • ERCC1 antibody
  • ERCC1_HUMAN antibody
  • Excision repair cross complementation group 1 antibody
  • Excision repair cross complementing 1 antibody
  • Excision Repair Cross Complementing Rodent Repair Deficiency Complementation Group 1 antibody
  • Excision repair protein antibody
  • RAD 10 antibody
  • RAD10 antibody
  • UV 20 antibody
  • UV20 antibody

  see all

プロトコール

• Western blot protocols
• Flow cytometry protocols