製品の概要

  • 製品名Anti-ERC1 antibody [ELKS-30]
    ERC1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [ELKS-30] to ERC1
  • アプリケーション適用あり: ICC/IF, WB, ELISA, IPmore details
  • 種交差性
    交差種: Mouse, Rat, Chicken, Cow, Human
    交差が予測される動物種: Zebrafish
  • 免疫原

    Synthetic peptide:

    SPRLPRSPRLGHRRTNSTGG

    , corresponding to amino acids 21 - 40 of Human ERC1

  • ポジティブ・コントロール
    • WB: HeLa cell extract.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab50312 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use at an assay dependent dilution.
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 120 kDa (predicted molecular weight: 128 kDa).
ELISA Use at an assay dependent dilution.
IP Use at an assay dependent dilution.

ターゲット情報

  • 機能Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.
  • 組織特異性Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested.
  • 関連疾患Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving ERC1/RAB6IP2 is found in cause of thyroid papillary carcinomas. Translocation t(10;12)(q11;p13) involving RET. In vitro, isoform 1, isoform 3 and isoform 5 participating in a ERC1-RET fusion protein activate tyrosine-protein kinase activity.
  • 配列類似性Contains 1 FIP-RBD domain.
  • 細胞内局在Cytoplasm. Membrane. Golgi apparatus membrane. In neurons, localized closed to presynaptic membrane. Recruited on Golgi membranes by RAB6A in a GTP-dependent manner.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Cast 2 antibody
    • CAST2 antibody
    • CAZ associated structural protein 2 antibody
    • Elks antibody
    • ELKS/RAB6 interacting/CAST family member 1 antibody
    • ELKS/RAB6-interacting/CAST family member 1 antibody
    • ERC 1 antibody
    • ERC protein 1 antibody
    • ERC-1 antibody
    • Erc1 antibody
    • ERC1 protein antibody
    • KIAA1081 antibody
    • MGC12974 antibody
    • RAB6 interacting protein 2 antibody
    • RAB6-interacting protein 2 antibody
    • RAB6IP2 antibody
    • RB6I2_HUMAN antibody
    see all

Anti-ERC1 antibody [ELKS-30] (ab50312) 使用論文

This product has been referenced in:
  • Chiu HC  et al. High-throughput quantitative proteomic analysis of dengue virus type 2 infected A549 cells. PLoS One 9:e93305 (2014). WB ; Human . Read more (PubMed: 24671231) »

See 1 Publication for this product

Product Wall

Application Western blot
Loading amount 30 µg
Gel Running Conditions Reduced Denaturing (10% gel)
Sample Zebrafish Tissue lysate - whole (Whole embryo)
Specification Whole embryo
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
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投稿 Mar 25 2015

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"