Anti-ErbB 3 (phospho Y1222) 抗体 (ab62434)

製品の概要

  • 製品名Anti-ErbB 3 (phospho Y1222) antibody
    ErbB 3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ErbB 3 (phospho Y1222)
  • 特異性This antibody detects endogenous levels of HER3/ErbB3 only when phosphorylated at tyrosine 1222.
  • アプリケーション適用あり: IHC-P, ICC/IF, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic phosphopeptide derived from human ErbB3 around the phosphorylation site of tyrosine 1222 (L-G-YP-E-Y).

  • ポジティブ・コントロール
    • Human brain tissue; HuvEc cells

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab62434 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100.
ICC/IF 1/500 - 1/1000.
ELISA 1/20000.

ターゲット情報

  • 機能Binds and is activated by neuregulins and NTAK.
  • 組織特異性Epithelial tissues and brain.
  • 関連疾患Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
    Contains 1 protein kinase domain.
  • 発生段階Overexpressed in a subset of human mammary tumors.
  • ドメインThe cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
  • 翻訳後修飾Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.
  • 細胞内局在Secreted and Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • c erbB 3 antibody
    • c erbB3 antibody
    • Erb b2 receptor tyrosine kinase 3 antibody
    • ErbB 3 antibody
    • ERBB3 antibody
    • ERBB3 protein antibody
    • erbB3 S antibody
    • ERBB3_HUMAN antibody
    • Glial growth factor receptor antibody
    • HER 3 antibody
    • HER3 antibody
    • Human epidermal growth factor receptor 3 antibody
    • LCCS2 antibody
    • MDA BF 1 antibody
    • MGC88033 antibody
    • p180 ErbB3 antibody
    • p45 sErbB3 antibody
    • p85 sErbB3 antibody
    • proto-oncogene-like protein c ErbB 3 antibody
    • proto-oncogene-like protein c ErbB3 antibody
    • Proto-oncogene-like protein c-ErbB-3 antibody
    • Receptor tyrosine protein kinase erbB 3 antibody
    • Receptor tyrosine protein kinase erbB3 antibody
    • Receptor tyrosine-protein kinase erbB-3 antibody
    • Tyrosine kinase type cell surface receptor HER3 antibody
    • Tyrosine kinase-type cell surface receptor HER3 antibody
    • v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody
    • v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody
    • v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody
    see all

Anti-ErbB 3 (phospho Y1222) antibody 画像

  • Immunohistochemical analysis of paraffin embedded human brain tissue using ab62434 at a 1/50 dilution, in the presence (right) and absence (left) of immunizing phosphopeptide.
  • Immunofluorescent analysis of HuvEc cells using ab62434 at a 1/500 dilution, in the presence (right) and absence (left) of immunizing phosphopeptide.

Anti-ErbB 3 (phospho Y1222) antibody (ab62434) 使用論文

ab62434 has not yet been referenced specifically in any publications.

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