Anti-ErbB3 / HER3 抗体 [SP71], prediluted (ab101544)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [SP71] to ErbB3 / HER3, prediluted
- Suitable for: IHC-P
- Reacts with: Human
Related conjugates and formulations
製品の概要
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製品名
Anti-ErbB3 / HER3 antibody [SP71], prediluted
ErbB3 / HER3 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [SP71] to ErbB3 / HER3, prediluted -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide within Human ErbB3/ HER3 aa 650-750 (internal sequence). The exact sequence is proprietary.
Database link: P21860 -
エピトープ
Internal region -
ポジティブ・コントロール
- Human small intestine
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特記事項
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: Tris buffered saline, 1% BSA -
Concentration information loading...
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精製度
Protein A/G purified -
特記事項(精製)
Purified from TCS by protein A/G. -
ポリ/モノ
モノクローナル -
クローン名
SP71 -
アイソタイプ
IgG -
研究分野
関連製品
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Alternative Versions
- Anti-ErbB3 / HER3 antibody [SP71] - BSA and Azide free (ab236220)
- Alexa Fluor® 488 Anti-ErbB 3 antibody [SP71] (ab309933)
- Alexa Fluor® 647 Anti-ErbB 3 antibody [SP71] (ab310300)
- Alexa Fluor® 594 Anti-ErbB 3 antibody [SP71] (ab310763)
- Alexa Fluor® 555 Anti-ErbB 3 antibody [SP71] (ab312290)
- Alexa Fluor® 568 Anti-ErbB3 / HER3 antibody [SP71] (ab312785)
- Anti-ErbB3 / HER3 antibody [SP71] (ab93739)
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab101544の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P |
1/1. (Prediluted). Antigen Retrieval: boil tissue section in 1mM EDTA, pH 8.0 for 10 minutes followed by cooling at room temperature for 20 minutes.
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特記事項 |
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IHC-P
1/1. (Prediluted). Antigen Retrieval: boil tissue section in 1mM EDTA, pH 8.0 for 10 minutes followed by cooling at room temperature for 20 minutes. |
ターゲット情報
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機能
Binds and is activated by neuregulins and NTAK. -
組織特異性
Epithelial tissues and brain. -
関連疾患
Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology. -
配列類似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Contains 1 protein kinase domain. -
発生段階
Overexpressed in a subset of human mammary tumors. -
ドメイン
The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins. -
翻訳後修飾
Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. -
細胞内局在
Secreted and Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 2065 Human
- Omim: 190151 Human
- SwissProt: P21860 Human
- Unigene: 118681 Human
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別名
- c erbB 3 antibody
- c erbB3 antibody
- Erb b2 receptor tyrosine kinase 3 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab101544 は 1 報の論文で使用されています。
- Huang J et al. The anti-erbB3 antibody MM-121/SAR256212 in combination with trastuzumab exerts potent antitumor activity against trastuzumab-resistant breast cancer cells. Mol Cancer 12:134 (2013). PubMed: 24215614