製品の概要

  • 製品名Anti-Ephrin A1 antibody
    Ephrin A1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Ephrin A1
  • 特異性ab109581 is expected to recognize isoform a (NP_004419.2) only.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat
    交差が予測される動物種: Dog, Human, Pig
  • 免疫原

    Synthetic peptide:

    C-KVTVSGKITHSP

    , corresponding to internal sequence amino acids 144-155 of Human Ephrin A1 (NP_004419.2).

  • ポジティブ・コントロール
    • Mouse Thymus and Rat Lung lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab109581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.01 - 0.03 µg/ml. Predicted molecular weight: 24 kDa.

ターゲット情報

  • 機能Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cones.
  • 組織特異性Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
  • 配列類似性Belongs to the ephrin family.
  • 翻訳後修飾Undergo proteolysis by a metalloprotease to give rise to a soluble monomeric form.
  • 細胞内局在Secreted and Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • B61 antibody
    • ECKLG antibody
    • EFL 1 antibody
    • EFL1 antibody
    • EFNA 1 antibody
    • Efna1 antibody
    • EFNA1_HUMAN antibody
    • EPH related receptor tyrosine kinase ligand 1 antibody
    • EPH-related receptor tyrosine kinase ligand 1 antibody
    • Ephrin-A1 antibody
    • Ephrin-A1, secreted form antibody
    • EphrinA1 antibody
    • EPLG 1 antibody
    • EPLG1 antibody
    • Immediate early response protein B61 antibody
    • LERK 1 antibody
    • LERK-1 antibody
    • LERK1 antibody
    • Ligand of eph related kinase 1 antibody
    • OTTHUMP00000033242 antibody
    • OTTHUMP00000033271 antibody
    • secreted form antibody
    • TNF alpha-induced protein 4 antibody
    • TNFAIP 4 antibody
    • TNFAIP4 antibody
    • Tumor necrosis factor alpha induced protein 4 antibody
    • Tumor necrosis factor alpha-induced protein 4 antibody
    see all

Anti-Ephrin A1 antibody 画像

  • Anti-Ephrin A1 antibody (ab109581) at 0.01 µg/ml + Mouse Thymus lysate (in RIPA buffer) at 35 µg

    Predicted band size : 24 kDa

Anti-Ephrin A1 antibody (ab109581) 使用論文

ab109581 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab109581.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"