Anti-Eph receptor B6 抗体 [RM0057-9B17] (ab73260)

製品の概要

  • 製品名Anti-Eph receptor B6 antibody [RM0057-9B17]
    Eph receptor B6 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [RM0057-9B17] to Eph receptor B6
  • 特異性ab73260 is specific for mouse Eph receptor B6. It does not cross-react with recombinant mouse EphA2, EphA3, EphA4, EphA6, EphA7 EphA8, EphB2, EphB3, and EphB4
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Recombinant mouse Eph receptor B6 extracellular domain

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab73260 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/1000. Predicted molecular weight: 110 kDa.
IHC-P 1/50 - 1/200.

ターゲット情報

  • 機能Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
  • 組織特異性Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 1 protein kinase domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • ドメインThe protein kinase domain is predicted to be catalytically inactive. Its extracellular domain is capable of promoting cell adhesion and migration in response to low concentrations of ephrin-B2, but its cytoplasmic domain is essential for cell repulsion and inhibition of migration induced by high concentrations of ephrin-B2.
  • 翻訳後修飾Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.
  • 細胞内局在Secreted and Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • EPH receptor B6 antibody
    • Ephb6 antibody
    • EPHB6_HUMAN antibody
    • Ephrin type B receptor 6 precursor antibody
    • Ephrin type-B receptor 6 antibody
    • HEP antibody
    • MGC129910 antibody
    • MGC129911 antibody
    • Tyrosine protein kinase defective receptor EPH 6 antibody
    • Tyrosine-protein kinase-defective receptor EPH-6 antibody
    see all

Anti-Eph receptor B6 antibody [RM0057-9B17] 画像

  • ab73260 at 1/200 dilution, staining Eph receptor B6 in LPS treated mouse kidney tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

Anti-Eph receptor B6 antibody [RM0057-9B17] (ab73260) 使用論文

ab73260 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab73260.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"