Anti-Eph receptor B2 抗体 (ab54650)

製品の概要

  • 製品名Anti-Eph receptor B2 antibody
    Eph receptor B2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to Eph receptor B2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Recombinant fragment: CIANAEEVDV PIKLYCNGDG EWLVPIGRCM CKAGFEAVEN GTVCRGCPSG TFKANQGDEA CTHCPINSRT TSEGATNCVC RNGYYRADLD PLDMPCTTIP , corresponding to amino acids 226-325 of Human Eph receptor B2

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab54650 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Receptor for members of the ephrin-B family. Phosphorylates ARHGEF15, leading to its ubiquitination and degradation by the proteasome which promotes EFNB1-dependent synapse formation. Can function in aspects of retinal ganglion cell axon guidance to the optic disk even when lacking its tyrosine kinase domain. Acts as a tumor suppressor.
    • 組織特異性Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
    • 関連疾患Defects in EPHB2 may be a cause of susceptibility to prostate cancer (PC) [MIM:176807]. It is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=EPHB2 mutations have been found in a prostate cancer cell line derived from a brain metastasis.
    • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
      Contains 2 fibronectin type-III domains.
      Contains 1 protein kinase domain.
      Contains 1 SAM (sterile alpha motif) domain.
    • 細胞内局在Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • cek5 antibody
      • Developmentally regulated EPH related tyrosine kinase antibody
      • DRT antibody
      • EK5 antibody
      • ELK related protein tyrosine kinase antibody
      • Eph receptor B2 antibody
      • EPH tyrosine kinase 3 antibody
      • EPH-like kinase 5 antibody
      • EPHB2 antibody
      • EPHB2_HUMAN antibody
      • Ephrin type B receptor 2 antibody
      • Ephrin type-B receptor 2 antibody
      • EPHT 3 antibody
      • ERK antibody
      • ETECK antibody
      • hEK5 antibody
      • Nuk antibody
      • Prkm 5 antibody
      • Receptor protein tyrosine kinase HEK 5 antibody
      • Renal carcinoma antigen NY-REN-47 antibody
      • Sek 3 antibody
      • Tyro 5 antibody
      • Tyrosine protein kinase receptor CEK 5 antibody
      • Tyrosine protein kinase receptor EPH 3 antibody
      • Tyrosine protein kinase receptor QEK 5 antibody
      • Tyrosine-protein kinase receptor EPH-3 antibody
      • Tyrosine-protein kinase TYRO5 antibody
      see all

    Anti-Eph receptor B2 antibody 画像



    • Predicted band size : 118 kDa
      Eph receptor B2 antibody (ab54650) at 1ug/lane + NIH/3T3 cell lysate at 25ug/lane.

    Anti-Eph receptor B2 antibody (ab54650) 使用論文

    ab54650 has not yet been referenced specifically in any publications.

    Product Wall

    Abcam has not validated the combination of species/application used in this Abreview.
    Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample Mouse Tissue sections (mouse lung containing artery)
    Specification mouse lung containing artery
    Fixative Formaldehyde
    Antigen retrieval step Heat mediated - Buffer/Enzyme Used: dako low pH
    Permeabilization No
    Blocking step HP as blocking agent for 30 minute(s) · Concentration: 2% · Temperature: RT°C
    Username

    Dr. mark southwood

    Verified customer

    投稿 Nov 10 2011

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"