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Recombinant fragment (extracellular domain) (Mouse). Expressed in NSO cells.
EphA4 (the antigen to this antibody) is also known Sek, Sek1, Cek8, Hek8 and Tyro1 and binds to ephrin-A5, ephrin-A1, ephrin-A3, ephrin-A2, ephrin-B2, ephrin-B3 and ephrin-A4. EphA4 can be detected in B cells, T cells and keratinocytes (ref 1,2). To date, at least 14 members of the Eph receptor family and a family of 8 ligands have been identified. Ligands of Eph family receptors are structurally related membrane-bound proteins that can be subdivided into two major subclasses: ephrin-A and ephrin-B (ref 2). Ligands in the ephrin-A subclass, including the prototype family member ephrin-A1 (B61), are membrane associated through glycosylphosphatidyl-inositol linkages, whereas ephrin-B subclass consists of ligands with transmembrane domains. The a general role of the Eph family is in mediating repulsive cell-cell interaction, as suggested by studies of axonal guidance and neural crest cell migration.
Our Abpromise guarantee covers the use of ab7039 in the following tested applications.
|WB||Use a concentration of 0.1 - 0.2 µg/ml.
WB (colourimetric): Use at a concentration of 0.1 - 0.2 µg/ml.
|Indirect ELISA||Use a concentration of 0.5 - 1 µg/ml.|
ab7039 has not yet been referenced specifically in any publications.