Anti-Eph receptor A2 抗体 [EPR4761] (ab110716)

製品の概要

  • 製品名Anti-Eph receptor A2 antibody [EPR4761]
    Eph receptor A2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR4761] to Eph receptor A2
  • アプリケーション適用あり: WBmore details
    適用なし: Flow Cyt,ICC,IHC-P or IP
  • 種交差性
    交差種: Human
  • 免疫原

    A synthetic peptide corresponding to residues in C-terminus of Human Eph receptor A2.

  • ポジティブ・コントロール
    • A431, 293T, SH SY5Y, and BxPC3 cell lysates.
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab110716 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Predicted molecular weight: 108 kDa.
  • 追加情報Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • ターゲット情報

    • 機能Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Induces apoptosis in a p53/TP53-independent, caspase-8-dependent manner.
    • 組織特異性Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g., skin, intestine, lung, and ovary.
    • 関連疾患Genetic variations in EPHA2 are the cause of susceptibility to cataract cortical age-related type 2 (ARCC2) [MIM:613020]. A developmental punctate opacity common in the cortex and present in most lenses. The cataract is white or cerulean, increases in number with age, but rarely affects vision.
      Defects in EPHA2 are the cause of cataract posterior polar type 1 (CTPP1) [MIM:116600]. A subcapsular opacity, usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity.
    • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
      Contains 2 fibronectin type-III domains.
      Contains 1 protein kinase domain.
      Contains 1 SAM (sterile alpha motif) domain.
    • 翻訳後修飾Activated by EFNA1 via tyrosine phosphorylation. Phosphorylated residues Tyr-588 and Tyr-594 are required for binding VAV2 and VAV3 while phosphorylated residues Tyr-735 and Tyr-930 are required for binding PI3-kinase p85 subunit. These phosphorylated residues are critical for recruitment of VAV2 and VAV3 and PI3-kinase p85 subunit which transduce downstream signaling to activate RAC1 GTPase and endothelial cell migration. They also play a critical role in transducing EPHA2 signaling in vascular endothelial cells during tumor angiogenesis.
    • 細胞内局在Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • ARCC2 antibody
      • AW545284 antibody
      • CTPA antibody
      • CTPP1 antibody
      • CTRCT6 antibody
      • EC 2.7.10.1 antibody
      • Eck antibody
      • Eph receptor A2 antibody
      • EPHA2 antibody
      • EPHA2_HUMAN antibody
      • Ephrin receptor antibody
      • Ephrin receptor EphA2 antibody
      • Ephrin type A receptor 2 antibody
      • Ephrin type-A receptor 2 antibody
      • Epithelial cell kinase antibody
      • Epithelial cell receptor protein tyrosine kinase antibody
      • Myk 2 antibody
      • Myk2 antibody
      • Sek 2 antibody
      • Sek2 antibody
      • Soluble EPHA2 variant 1 antibody
      • Tyrosine protein kinase receptor ECK antibody
      • Tyrosine-protein kinase receptor ECK antibody
      • Tyrosine-protein kinase receptor MPK-5 antibody
      • Tyrosine-protein kinase receptor SEK-2 antibody
      see all

    Anti-Eph receptor A2 antibody [EPR4761] 画像

    • All lanes : Anti-Eph receptor A2 antibody [EPR4761] (ab110716) at 1/1000 dilution

      Lane 1 : A431 cell lysate
      Lane 2 : 293T cell lysate
      Lane 3 : SH SY5Y cell lysate
      Lane 4 : BxPC3 cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 108 kDa

    Anti-Eph receptor A2 antibody [EPR4761] (ab110716) 使用論文

    ab110716 has not yet been referenced specifically in any publications.

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