Anti-Eph receptor A1 抗体 [MM0260- 8D36] (ab89471)

製品の概要

  • 製品名Anti-Eph receptor A1 antibody [MM0260- 8D36]
    Eph receptor A1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MM0260- 8D36] to Eph receptor A1
  • アプリケーション適用あり: WB, IHC-Frmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant Human Eph receptor A1

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab89471 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 108 kDa.
IHC-Fr 1/20 - 1/100.

ターゲット情報

  • 機能Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
  • 組織特異性Overexpressed in several carcinomas.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
    Contains 1 Eph LBD (Eph ligand-binding) domain.
    Contains 2 fibronectin type-III domains.
    Contains 1 protein kinase domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • 翻訳後修飾Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1.
    Ubiquitinated.
  • 細胞内局在Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • EPH antibody
    • EPH receptor A1 antibody
    • EPH tyrosine kinase 1 antibody
    • EPH tyrosine kinase antibody
    • Epha1 antibody
    • EPHA1_HUMAN antibody
    • Ephrin receptor Eph A1 antibody
    • Ephrin type A receptor 1 antibody
    • Ephrin type-A receptor 1 antibody
    • EPHT 1 antibody
    • EPHT antibody
    • EPHT1 antibody
    • Erythropoietin producing hepatoma amplified sequence antibody
    • Erythropoietin-producing hepatoma receptor antibody
    • Esk antibody
    • hEpha1 antibody
    • MGC163163 antibody
    • Oncogene EPH antibody
    • Soluble EPHA1 variant 1 antibody
    • Soluble EPHA1 variant 2 antibody
    • Tyrosine protein kinase receptor EPH antibody
    • Tyrosine-protein kinase receptor EPH antibody
    see all

Anti-Eph receptor A1 antibody [MM0260- 8D36] 画像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human placental tissue section (4µm) labelling Eph receptor A1 with ab89471. Tissue was treated with 15µg/ml Protenase K for antigen retrieval and fixed with 4% PFA. A HRP-conjugated anti-mouse IgG was used as the secondary antibody (30 minutes at room temperature) followed by DAB color development.

Anti-Eph receptor A1 antibody [MM0260- 8D36] (ab89471) 使用論文

ab89471 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"