Anti-Eph receptor A1 抗体 - Carboxyterminal end (ab37857)

製品の概要

  • 製品名Anti-Eph receptor A1 antibody - Carboxyterminal end
    Eph receptor A1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Eph receptor A1 - Carboxyterminal end
  • アプリケーション適用あり: ELISA, WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    This antobody is generated from rabbits immunozed with a KLH conjugated synthetic peptide selected from aa 934-950 (FHSAGLDTMECVLELTA) of human EphA1

  • ポジティブ・コントロール
    • HeLa cell lysate. breast carcinoma

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab37857 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 108 kDa (predicted molecular weight: 108 kDa).
IHC-P 1/50 - 1/100.

ターゲット情報

  • 機能Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
  • 組織特異性Overexpressed in several carcinomas.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
    Contains 1 Eph LBD (Eph ligand-binding) domain.
    Contains 2 fibronectin type-III domains.
    Contains 1 protein kinase domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • 翻訳後修飾Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1.
    Ubiquitinated.
  • 細胞内局在Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • EPH antibody
    • EPH receptor A1 antibody
    • EPH tyrosine kinase 1 antibody
    • EPH tyrosine kinase antibody
    • Epha1 antibody
    • EPHA1_HUMAN antibody
    • Ephrin receptor Eph A1 antibody
    • Ephrin type A receptor 1 antibody
    • Ephrin type-A receptor 1 antibody
    • EPHT 1 antibody
    • EPHT antibody
    • EPHT1 antibody
    • Erythropoietin producing hepatoma amplified sequence antibody
    • Erythropoietin-producing hepatoma receptor antibody
    • Esk antibody
    • hEpha1 antibody
    • MGC163163 antibody
    • Oncogene EPH antibody
    • Soluble EPHA1 variant 1 antibody
    • Soluble EPHA1 variant 2 antibody
    • Tyrosine protein kinase receptor EPH antibody
    • Tyrosine-protein kinase receptor EPH antibody
    see all

Anti-Eph receptor A1 antibody - Carboxyterminal end 画像

  • Anti-Eph receptor A1 antibody - Carboxyterminal end (ab37857) at 1/100 dilution + HeLa cell lysate

    Secondary
    HRP-anti-rabbit
    Developed using the ECL technique

    Predicted band size : 108 kDa
    Observed band size : 108 kDa
    Additional bands at : 60 kDa. We are unsure as to the identity of these extra bands.
  • Immunohistochemical analysis of Ephrin A1 Receptor in formalin-fixed, paraffin-embedded human breast carcinoma using 1/50 ab37857.

Anti-Eph receptor A1 antibody - Carboxyterminal end (ab37857) 使用論文

ab37857 has not yet been referenced specifically in any publications.

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