製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to EPC1
  • アプリケーション
    適用あり: WB, IPmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Cow, Dog, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Elephant
  • 免疫原

    Synthetic peptide, corresponding to a region between amino acids 325-375 of Human EPC1 (NP_079485.1).

  • ポジティブ・コントロール
    • HeLa whole cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab112043 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/2000 - 1/10000. Predicted molecular weight: 93 kDa.
IP Use at 2-10 µg/mg of lysate.

ターゲット情報

  • 機能
    Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.
  • 配列類似性
    Belongs to the enhancer of polycomb family.
  • 細胞内局在
    Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DKFZp781P2312 antibody
    • Enhancer of polycomb 1 antibody
    • Enhancer of polycomb homolog 1 (Drosophila) antibody
    • Enhancer of polycomb homolog 1 antibody
    • EPC1 antibody
    • EPC1_HUMAN antibody
    • Epl 1 antibody
    • Epl1 antibody
    • OTTHUMP00000046260 antibody
    see all

画像

  • All lanes : Anti-EPC1 antibody (ab112043) at 0.1 µg/ml

    Lane 1 : HeLa whole cell lysate at 50 µg
    Lane 2 : HeLa whole cell lysate at 15 µg
    Lane 3 : HeLa whole cell lysate at 5 µg

    Developed using the ECL technique

    Predicted band size : 93 kDa


    Exposure time : 3 minutes
  • Detection of EPC1 by Western Blot of Immunprecipitate.
    ab112043 at 1µg/ml staining EPC1 in HeLa whole cell lysate immunoprecipitated using ab112043 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 10 seconds.

参考文献

This product has been referenced in:
  • Wang Y  et al. Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures. Nucleic Acids Res 44:117-33 (2016). ChIP . Read more (PubMed: 26350215) »

See 1 Publication for this product

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