製品の概要

  • 製品名Anti-EPB41 antibody
    EPB41 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to EPB41
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 107 - 156 (EKGEGGQKEI EFGTSLDEEI ILKAPIAAPE PELKTDPSLD LHSLSSAETQ) of Human EPB41 (NP_976218; UniProt ID: P11171 isoform 5).

  • ポジティブ・コントロール
    • Human fetal spleen lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab98854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: for isoform 5, 87 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.
  • 関連疾患Defects in EPB41 are the cause of elliptocytosis type 1 (EL1) [MIM:611804]. EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
    Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:266140]. HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.
  • 配列類似性Contains 1 FERM domain.
  • 翻訳後修飾Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.
    Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex.
    O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.
  • 細胞内局在Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 4.1R antibody
    • 41_HUMAN antibody
    • Band 4.1 antibody
    • E41P antibody
    • EL 1 antibody
    • EL1 antibody
    • EL1 gene antibody
    • Elliptocytosis 1 antibody
    • Elliptocytosis 1 RH linked antibody
    • EPB 4.1 antibody
    • EPB 41 antibody
    • EPB4.1 antibody
    • Epb41 antibody
    • Erythrocyte membrane protein band 4.1 (elliptocytosis 1 RH linked) antibody
    • Erythrocyte membrane protein band 4.1 antibody
    • Erythrocyte surface protein band 4.1 antibody
    • HE antibody
    • P4.1 antibody
    • Protein 4.1 antibody
    • Protein 4.1, red blood cell type antibody
    see all

Anti-EPB41 antibody 画像

  • Anti-EPB41 antibody (ab98854) at 1 µg/ml + Human fetal spleen lysate at 10 µg

    Predicted band size : for isoform 5, 87 kDa

Anti-EPB41 antibody (ab98854) 使用論文

ab98854 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab98854.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"