製品の概要

  • 製品名Anti-Epac1 antibody
    Epac1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Epac1
  • 特異性ab21235 does not cross react with Epac 2.
  • アプリケーション適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    PRSCSYQLLLEHQRPSCI

    , corresponding to amino acids 9-26 of Epac1. Also, synthetic peptide: CRPDHSVLTLQLPVTASVR, corresponding to amino acids 522-540 of Epac1.

  • 特記事項Ab21235 is supplied in an antibody stabilisation buffer.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab21235 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500. Predicted molecular weight: 99 kDa.
ELISA 1/10000.
IHC-P Use at an assay dependent concentration. PubMed: 20663796

ターゲット情報

  • 関連性The activation of RaP1 by cAMP is independent of PKA and is mediated by recently discovered family of guanine nucleotide exchange factors (GEFs) called cAMP-GEFs or Epacs. The Epac signaling therefore represents a novel mechanism for cAMP signaling with in the cAMP cascade. There are 2 members of the Epac family, Epac1 and Epac 2. Both proteins are multidomain proteins containing an autoinhibitory cAMP-binding domain that inhibits the catalytic region and a DEP domain (dishevelled, Egl-10 and pleckstrin homology domain) targeting the membrane anchors. EPAC2 has an additional cAMP-binding site in its N-terminus that binds cAMP with low affinity. EPAC1 mRNA is broadly expressed, with particularly high levels occurring in the thyroid, ovary, kidney and certain brain regions, whereas expression of EPAC2 mRNA appears to be restricted to the brain and adrenal glands. Epac 1 and Epac 2 also interact with light chain 2 (LC2) or MAP1A that serves as a scaffolding structure to stabilize the signal transduction complex. The Epac 1-selective antibodies were generated against unique antigenic sequences form near N-terminus and between RasGEFN and Ras GEF domains. The antibodies to Epac 1are affinity purified over immobilized antigen based chromatography.
  • 細胞内局在Endomembrane system
  • 参照データベース
  • 別名
    • bcm910 antibody
    • CAMP GEFI antibody
    • cAMP regulated guanine nucleotide exchange factor I antibody
    • CAMPGEFI antibody
    • CGEF 1 antibody
    • CGEF1 antibody
    • EPA1 antibody
    • Epac 1 antibody
    • EPAC antibody
    • EPAC1 antibody
    • Exchange factor directly activated by cAMP 1 antibody
    • Exchange protein directly activated by cAMP 1 antibody
    • MGC21410 antibody
    • RAP guanine nucleotide exchange factor antibody
    • Rap guanine nucleotide exchange factor (GEF) 3 antibody
    • RAP guanine nucleotide exchange factor 3 antibody
    • Rap1 guanine nucleotide exchange factor directly activated by cAMP antibody
    • RAPGEF3 antibody
    see all

Anti-Epac1 antibody (ab21235) 使用論文

This product has been referenced in:
  • Yoshie M  et al. Possible role of the exchange protein directly activated by cyclic AMP (Epac) in the cyclic AMP-dependent functional differentiation and syncytialization of human placental BeWo cells. Hum Reprod 25:2229-38 (2010). WB, IHC-P ; Human . Read more (PubMed: 20663796) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"