機能Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
組織特異性Intestinal brush border.
関連疾患Defects in TMPRSS15 are a cause of enterokinase deficiency (ENTKD) [MIM:226200]; a life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive.
配列類似性Belongs to the peptidase S1 family. Contains 2 CUB domains. Contains 2 LDL-receptor class A domains. Contains 1 MAM domain. Contains 1 peptidase S1 domain. Contains 1 SEA domain. Contains 1 SRCR domain.
翻訳後修飾The chains are derived from a single precursor that is cleaved by a trypsin-like protease.