製品の概要

  • 製品名
    Anti-Endothelin 3 antibody (Biotin)
    Endothelin 3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Endothelin 3 (Biotin)
  • 標識
    Biotin
  • アプリケーション
    適用あり: IP, RIA, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide:

    CTCFTYKDKECVYYCHLDIIW

    conjugated to KLH, corresponding to amino acids 97-117 of Human Endothelin 3

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab48253 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at an assay dependent dilution.
RIA Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 機能
    Endothelins are endothelium-derived vasoconstrictor peptides.
  • 組織特異性
    Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells.
  • 関連疾患
    Defects in EDN3 are the cause of Hirschsprung disease type 4 (HSCR4) [MIM:613712]; also known as aganglionic megacolon (MGC). A genetic disorder of neural crest development characterized by the absence of intramural ganglion cells in the hindgut; often resulting in intestinal obstruction.
    Defects in EDN3 are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
    Defects in EDN3 are a cause of Waardenburg syndrome type 4 (WS4B) [MIM:613265]; also known as Waardenburg-Shah syndrome. WS4B is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).
  • 配列類似性
    Belongs to the endothelin/sarafotoxin family.
  • 細胞内局在
    Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • EDN3 antibody
    • EDN3_HUMAN antibody
    • Endothelin-3 antibody
    • ET 3 antibody
    • ET-3 antibody
    • PPET3 antibody
    • Preproendothelin 3 antibody
    • Preproendothelin-3 antibody
    see all

プロトコール

参考文献

ab48253 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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