機能Endothelins are endothelium-derived vasoconstrictor peptides.
組織特異性Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells.
関連疾患Defects in EDN3 are the cause of Hirschsprung disease type 4 (HSCR4) [MIM:613712]; also known as aganglionic megacolon (MGC). A genetic disorder of neural crest development characterized by the absence of intramural ganglion cells in the hindgut; often resulting in intestinal obstruction. Defects in EDN3 are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. Defects in EDN3 are a cause of Waardenburg syndrome type 4 (WS4B) [MIM:613265]; also known as Waardenburg-Shah syndrome. WS4B is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).
配列類似性Belongs to the endothelin/sarafotoxin family.
Anti-Endothelin 3 antibody (ab96709) at 1/1000 dilution + Raji whole cell lysate at 30 µg
Predicted band size : 25 kDa
Anti-Endothelin 3 antibody (ab96709) 使用論文
This product has been referenced in:
Liu Y et al. Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells. Mol Cancer Res9:1668-85 (2011).
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