製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 配列
      Two 14 amino acid synthetic peptides whose sequences are derived from amino acids 119-142 of mouse and human endostatin protein. The sequences of these peptides are (amino to carboxy terminus): R(129)RLM/TESYCETWRTE(142).
    • 領域
      119 to 142

関連製品

特性

Our Abpromise guarantee covers the use of ab4983 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態
    Liquid
  • 備考


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse/human endostatin, catalog ab3453. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

関連情報

  • 別名
    • Alpha 1 collagen type 18 (XVIII)(COL18A1)
    • Alpha 1 type XVIII collagen
    • Antiangiogenic agent
    • COIA1_HUMAN
    • COL15A1
    • Col18a1
    • Collagen alpha 1(XV) chain
    • Collagen alpha 1(XVIII) chain
    • Collagen alpha-1(XV) chain
    • Collagen type XV proteoglycan
    • Collagen type XVIII alpha 1
    • Collagen XV, alpha 1 polypeptide
    • Collagen, type XV, alpha 1
    • Endostatin
    • Endostatin XV
    • FLJ27325
    • FLJ34914
    • FLJ38566
    • KNO
    • KNO1
    • KS
    • MGC74745
    • Multi functional protein MFP
    • OTTHUMP00000021782
    • OTTHUMP00000115472
    • OTTHUMP00000115473
    see all
  • 機能
    COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
    Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
  • 組織特異性
    Present in multiple organs with highest levels in liver, lung and kidney.
  • 関連疾患
    Defects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.
  • 配列類似性
    Belongs to the multiplexin collagen family.
    Contains 1 FZ (frizzled) domain.
    Contains 1 TSP N-terminal (TSPN) domain.
  • 翻訳後修飾
    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • 細胞内局在
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

参考文献

ab4983 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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