Anti-Emerin 抗体 [MANEM1(5D10)] (ab125932)

製品の概要

  • 製品名Anti-Emerin antibody [MANEM1(5D10)]
    Emerin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MANEM1(5D10)] to Emerin
  • アプリケーション適用あり: ICC/IF, WBmore details
  • 種交差性
    交差種: Rabbit, Human
    非交差種: Mouse
  • 免疫原

    Recombinant fragment of Emerin amino acids 1-188(Human)

  • ポジティブ・コントロール
    • Human fibroblast cells and cell extracts.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • クローン名MANEM1(5D10)
  • ミエローマSp2/0
  • アイソタイプIgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab125932 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF 1/4 - 1/10.
WB 1/400 - 1/800. Predicted molecular weight: 29 kDa.

ターゲット情報

  • 機能Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
  • 組織特異性Skeletal muscle, heart, colon, testis, ovary and pancreas.
  • 関連疾患Defects in EMD are the cause of Emery-Dreifuss muscular dystrophy type 1 (EDMD1) [MIM:310300]. A degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects.
  • 配列類似性Contains 1 LEM domain.
  • 翻訳後修飾Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle.
  • 細胞内局在Nucleus inner membrane. Nucleus outer membrane. Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • EDMD antibody
    • Emd antibody
    • EMD_HUMAN antibody
    • Emerin antibody
    • Emery Dreifuss muscular dystrophy antibody
    • STA antibody
    see all

Anti-Emerin antibody [MANEM1(5D10)] 画像

  • Anti-Emerin antibody [MANEM1(5D10)] (ab125932) at 1/400 dilution + Normal Human fibroblast extracts

    Predicted band size : 29 kDa
  • ab125932 at 1/4 dilution staining Emerin in Human fibroblasts by Immunofluorescence. DAPI counterstaining.

Anti-Emerin antibody [MANEM1(5D10)] (ab125932) 使用論文

ab125932 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"