製品の概要

  • 製品名Anti-ELMO2 antibody
    ELMO2 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to ELMO2
  • 特異性This antibody is expected to recognise both human isoforms.
  • アプリケーション適用あり: IHC-P, ICC/IF, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide: PKEPSSYDFVYHYG, corresponding to C terminal amino acids 707-720 of Human ELMO2.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab2240 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 3 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use at an assay dependent concentration. PubMed: 24446484
WB Use a concentration of 1 - 3 µg/ml. Can be blocked with Human ELMO2 peptide (ab22879).

ターゲット情報

  • 機能Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
  • 組織特異性Widely expressed, with a higher expression in skeletal muscle, kidney and placenta.
  • 配列類似性Contains 1 ELMO domain.
    Contains 1 PH domain.
  • 細胞内局在Cytoplasm. Cytoplasm > cytosol. Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CED 12 antibody
    • Ced 12 homolog 2 antibody
    • CED 12 homolog A antibody
    • CED 12A antibody
    • CED-12 antibody
    • ced-12 homolog 2 antibody
    • CED12 antibody
    • CED12 homolog A antibody
    • CED12, C. elegans, homolog of, 2 antibody
    • CED12A antibody
    • ELMO 2 antibody
    • ELMO-2 antibody
    • ELMO2 antibody
    • ELMO2_HUMAN antibody
    • Engulfment and cell motility 2 (ced 12 homolog, C. elegans) antibody
    • Engulfment and cell motility 2 antibody
    • Engulfment and cell motility gene 2 antibody
    • Engulfment and cell motility protein 2 antibody
    • FLJ11656 antibody
    • hCED 12A antibody
    • hCED-12A antibody
    • hCED12A antibody
    • KIAA1834 antibody
    • OTTHUMP00000031762 antibody
    • PH domain protein CED12A antibody
    • Protein ced 12 homolog A antibody
    • Protein ced-12 homolog A antibody
    see all

Anti-ELMO2 antibody 画像

  • Ab2240 staining (2µg/ml) of Human Brain lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.
  • ab2240 at 3.8 µg/ml staining ELMO2 in Human prostate tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

Anti-ELMO2 antibody (ab2240) 使用論文

This product has been referenced in:
  • Toret CP  et al. A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell-cell adhesion. J Cell Biol 204:265-79 (2014). ICC/IF, WB ; Drosophila melanogaster . Read more (PubMed: 24446484) »
  • Toret CP  et al. An Elmo-Dock complex locally controls Rho GTPases and actin remodeling during cadherin-mediated adhesion. J Cell Biol 207:577-87 (2014). Read more (PubMed: 25452388) »

See all 5 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"