製品の概要

  • 製品名Anti-ELK1 antibody [7E10D5]
    ELK1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [7E10D5] to ELK1
  • 特異性This antibody is specific for ELK1.
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Ni-NTA purified truncated recombinant ELK1 expressed in E. Coli strain BL21 (DE3)

  • ポジティブ・コントロール
    • K562 cell lysate

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab47712 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 40, 77 kDa (predicted molecular weight: 45 kDa).
ELISA 1/10000.

ターゲット情報

  • 機能Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element.
  • 組織特異性Lung and testis.
  • 配列類似性Belongs to the ETS family.
    Contains 1 ETS DNA-binding domain.
  • 翻訳後修飾Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.
    On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ELK 1 antibody
    • Elk1 antibody
    • ELK1 member of ETS oncogene family antibody
    • ELK1 protein antibody
    • ELK1_HUMAN antibody
    • ELK2 member of ETS oncogene family antibody
    • ETS domain containing protein Elk 1 antibody
    • ETS domain containing protein Elk1 antibody
    • ETS domain protein Elk1 antibody
    • ETS domain-containing protein Elk-1 antibody
    • ETS like gene 1 antibody
    • Member of ETS oncogene family antibody
    • Oncogene Elk1 antibody
    • Tyrosine kinase (ELK1) oncogene antibody
    see all

Anti-ELK1 antibody [7E10D5] 画像

  • All lanes : Anti-ELK1 antibody [7E10D5] (ab47712) at 1/500 dilution

    Lane 1 : truncated recombinant ELK1
    Lane 2 : K562 cell lysate


    Predicted band size : 45 kDa
    Observed band size : 40,77 kDa (why is the actual band size different from the predicted?)

Anti-ELK1 antibody [7E10D5] (ab47712) 使用論文

ab47712 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"