Anti-eIF5A 抗体 (ab32014)

製品の概要

• 製品名Anti-eIF5A antibody
  eIF5A 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to eIF5A
• アプリケーション適用あり: WB, ICC, Flow Cyt, IHC-Pmore details
  適用なし: IP
• 種交差性
  交差種: Mouse, Rat, Human
  
• 免疫原

  Synthetic peptide corresponding to residues close to the C terminus of eIF5A (Human)

• ポジティブ･コントロール
  • Jurkat cell lysate, Human lung carcinoma

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファーPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Concentration information loading...
• 精製度Protein A purified
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • Translation
  • Regulation

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • RNA Processing
  • RNAi

  • Epigenetics and Nuclear Signaling
  • RNAi
  • Eukaryotic Initiation factors (eIF's)

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • Lung tumor (human): large cell carcinoma tissue slides (ab4886)
  • Lung tumor (human): small cell carcinoma tissue slides (ab4892)
  • Jurkat whole cell lysate (ab7899)

アプリケーション

ターゲット情報

• 機能mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
• 組織特異性Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).
• 配列類似性Belongs to the eIF-5A family.
• 翻訳後修飾eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
• 細胞内局在Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Nucleus > nuclear pore complex. Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.

• Target information above from: UniProt accession P63241 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 1984 Human
  • Entrez Gene: 276770 Mouse
  • Entrez Gene: 287444 Rat
  • Omim: 600187 Human
  • SwissProt: P63241 Human
  • SwissProt: P63242 Mouse
  • SwissProt: Q3T1J1 Rat
  • Unigene: 534314 Human

  • Unigene: 729454 Human
  • Unigene: 18026 Mouse
  • Unigene: 128212 Rat

  see all
• 別名
  • eIF 4D antibody
  • eIF 5A 1 antibody
  • EIF 5A antibody

  • eIF 5A1 antibody
  • eIF-4D antibody
  • eIF-5A antibody
  • eIF-5A-1 antibody
  • eIF-5A1 antibody
  • eIF4D antibody
  • eif5a antibody
  • EIF5A1 antibody
  • eIF5AI antibody
  • Eukaryotic initiation factor 5A antibody
  • Eukaryotic initiation factor 5A isoform 1 antibody
  • Eukaryotic translation initiation factor 5A 1 antibody
  • Eukaryotic translation initiation factor 5A antibody
  • Eukaryotic translation initiation factor 5A-1 antibody
  • IF5A1_HUMAN antibody
  • MGC104255 antibody
  • MGC99547 antibody
  • Rev binding factor antibody
  • Rev-binding factor antibody
  • uORF A antibody
  • uORF antibody

  see all