Mouse, Rat, Chimpanzee, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan
A region between residue 198 and 248 of human eIF4H using the numbering given in entry NP_071496.1
HeLa cells lysate
293T cells lysate
特記事項Shelf Life: 1 year from date of receipt
保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
バッファーPreservative: 0.09% Sodium Azide
Constituents: 0.1% BSA, Tris buffered saline
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精製度Immunogen affinity purified
特記事項（精製）Affinity purified using an epitope specific to eIF4H immobilized on solid support. Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.
機能Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
組織特異性The short isoform is the predominant isoform and is expressed alone in liver and skeletal muscle. Both isoforms are expressed in fibroblast, spleen, testis and bone marrow. Levels are high in lung and pancreas and low in heart, frontal cortex and kidney.
関連疾患Note=EIF4H is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of EIF4H may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.