Anti-eIF2B3 抗体 - Carboxyterminal end (ab71248)

製品の概要

  • 製品名Anti-eIF2B3 antibody - Carboxyterminal end
    eIF2B3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to eIF2B3 - Carboxyterminal end
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to Human eIF2B3 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH).

  • ポジティブ・コントロール
    • A375 cell line lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Ammonium Sulphate Precipitation
  • 特記事項(精製)This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab71248 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Detects a band of approximately 27 kDa (predicted molecular weight: 32 kDa).
ELISA 1/1000.

ターゲット情報

  • 機能Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
  • 関連疾患Defects in EIF2B3 are a cause of leukodystrophy with vanishing white matter (VWM) [MIM:603896]. VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.
  • 配列類似性Belongs to the eIF-2B gamma/epsilon subunits family.
  • Information by UniProt
  • 参照データベース
  • 製品の状態It localizes to the cytosol.
  • 別名
    • EI2BG_HUMAN antibody
    • EIF 2B antibody
    • eIF 2B GDP GTP exchange factor subunit gamma antibody
    • eIF-2B GDP-GTP exchange factor subunit gamma antibody
    • eIF2B-gamma antibody
    • Eif2b3 antibody
    • EIF2Bgamma antibody
    • Eukaryotic translation initiation factor 2B subunit 3 gamma antibody
    • Eukaryotic translation initiation factor 2B, gamma antibody
    • eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa antibody
    • OTTHUMP00000010262 antibody
    • OTTHUMP00000010263 antibody
    • Translation initiation factor eIF-2B subunit gamma antibody
    see all

Anti-eIF2B3 antibody - Carboxyterminal end 画像

  • Anti-eIF2B3 antibody - Carboxyterminal end (ab71248) at 1/100 dilution + A375 cell line lysate at 12.5 µg

    Predicted band size : 32 kDa
    Observed band size : 27 kDa (why is the actual band size different from the predicted?)

Anti-eIF2B3 antibody - Carboxyterminal end (ab71248) 使用論文

ab71248 has not yet been referenced specifically in any publications.

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