製品の概要

  • 製品名Anti-EFEMP1 antibody
    EFEMP1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to EFEMP1
  • 特異性ab106429 is predicted not to cross-react with other Fibulin proteins.
  • アプリケーション適用あり: ICC/IF, WB, ICCmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human EFEMP1 (C terminal).
    Database link: Q12805

  • ポジティブ・コントロール
    • HeLa cell lysate.
  • 特記事項

    Antibodies should not be exposed to prolonged high temperatures.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab106429 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 55 kDa.
ICC Use a concentration of 20 µg/ml.

ターゲット情報

  • 機能Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
  • 組織特異性In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina.
  • 関連疾患Defects in EFEMP1 are a cause of Doyne honeycomb retinal dystrophy (DHRD) [MIM:126600]; also known as malattia leventinese (MLVT) (ML). DHRD is an autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium.
  • 配列類似性Belongs to the fibulin family.
    Contains 6 EGF-like domains.
  • 細胞内局在Secreted > extracellular space. Secreted > extracellular space > extracellular matrix. Localizes to the lamina propria underneath the olfactory epithelium.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DHRD antibody
    • Doyne honeycomb retinal degeneration antibody
    • DRAD antibody
    • EFEMP 1 antibody
    • EFEMP1 antibody
    • EGF containing fibulin like extracellular matrix protein 1 antibody
    • EGF containing fibulin like extracellular matrix protein 1 precursor antibody
    • EGF-containing fibulin-like extracellular matrix protein 1 antibody
    • Epidermal growth factor containing fibulin like extracellular matrix protein 1 antibody
    • Extracellular protein S1 5 antibody
    • Extracellular protein S1-5 antibody
    • FBLN 3 antibody
    • FBLN3 antibody
    • FBLN3_HUMAN antibody
    • FBNL antibody
    • FIBL 3 antibody
    • FIBL-3 antibody
    • FIBL3 antibody
    • Fibrillin like antibody
    • Fibrillin like protein antibody
    • Fibrillin-like protein antibody
    • FIBULIN 3 antibody
    • Fibulin-3 antibody
    • Fibulin3 antibody
    • FLJ35535 antibody
    • Heat shock 70 KD protein 1 antibody
    • MGC111353 antibody
    • MLVT antibody
    • MTLV antibody
    • S1 5 antibody
    • T16 protein antibody
    see all

Anti-EFEMP1 antibody 画像

  • Lane 1 : Anti-EFEMP1 antibody (ab106429) at 0.5 µg/ml
    Lane 2 : Anti-EFEMP1 antibody (ab106429) at 1 µg/ml

    Lane 1 : HeLa cell lysate
    Lane 2 : HeLa cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 55 kDa
  • Immunohistochemical analysis of HeLa cells labelling EFEMP1 with ab106429 at 20 µg/ml. 

  • Immunofluorescence analysis of Hela cells labelling Fibulin 3 with ab106429 at 20 ug/ml.

Anti-EFEMP1 antibody (ab106429) 使用論文

ab106429 has not yet been referenced specifically in any publications.

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