製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to EDF1
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide: AESDWDTVTVLRK-C, corresponding to amino acids 2-14 of Human EDF1 (NP_003783.1).

  • ポジティブ・コントロール
    • Human Brain, Cortex and Pancreas tissues

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab118583 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 3.75 - 7.5 µg/ml.

ターゲット情報

  • 機能
    Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.
  • 組織特異性
    Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues.
  • 配列類似性
    Contains 1 HTH cro/C1-type DNA-binding domain.
  • 発生段階
    Expressed in fetal tissues. More abundant in kidney.
  • ドメイン
    The IQ motif, which is involved in calmodulin binding, overlaps with the binding domain for nuclear receptors and transcription factors. Its phosphorylation probably allows a switch between the two activities of the protein.
  • 翻訳後修飾
    Phosphorylated (by PKA and PKC).
  • 細胞内局在
    Cytoplasm. Nucleus. Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CAP19 antibody
    • EDF-1 antibody
    • edf1 antibody
    • EDF1_HUMAN antibody
    • Endothelial differentiation related factor 1 antibody
    • Endothelial differentiation-related factor 1 antibody
    • MBF1 antibody
    • MGC9058 antibody
    • Multiprotein bridging factor 1 antibody
    • Multiprotein-bridging factor 1 antibody
    see all

画像

  • ab118583, at 7.5 µg/ml, staining EDF1 in formalin-fixed, paraffin-embedded Human Brain, Cortex tissue by Immunohistochemistry.
  • ab118583, at 7.5 µg/ml, staining EDF1 in formalin-fixed, paraffin-embedded Human Pancreas tissue by Immunohistochemistry.

プロトコール

参考文献

ab118583 has not yet been referenced specifically in any publications.

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