製品の概要

  • 製品名Anti-EDARADD antibody
  • 製品の詳細
    Rabbit polyclonal to EDARADD
  • アプリケーション適用あり: ICC/IF, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen sequence: PTISDLLNDQ DLLDVIRIKL DPCHPTVKNW RNFASKWGMS YDELCFLEQR PQSPTLEFLL RNSQRTVGQL MELCRLYHRA DVEKVLRRWV DEEWPKRERG DP, corresponding to amino acids 110-211 of Human EDARADD

  • ポジティブ・コントロール
    • Human duodenum tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab121581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Use buffer at pH 6 for antigen retrieval.

ターゲット情報

  • 機能Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B.
  • 組織特異性Detected in adult pancreas, placenta and fetal skin, and at lower levels in lung, thymus, prostate and testis.
  • 関連疾患Defects in EDARADD are a cause of ectodermal dysplasia anhidrotic (EDA) [MIM:224900]; also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
  • 配列類似性Contains 1 death domain.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Cr antibody
    • Crinkled homolog antibody
    • ectodysplasia A receptor associated death domain antibody
    • Ectodysplasin-A receptor-associated adapter protein antibody
    • ED3 antibody
    • EDA3 antibody
    • EDAD_HUMAN antibody
    • EDAR associated death domain antibody
    • EDAR-associated death domain protein antibody
    • EDARADD antibody
    • Protein crinkled homolog antibody
    see all

Anti-EDARADD antibody 画像

  • Immunofluorescent staining of Human cell line A-431 shows positivity in nucleus but not nucleoli and cytoplasm. Recommended concentration of ab121581 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab121581 at a 1/75 dilution, staining EDARADD in glandular cells of paraffin-embedded Human duodenum tissue by immunohistochemistry.

Anti-EDARADD antibody (ab121581) 使用論文

ab121581 has not yet been referenced specifically in any publications.

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