製品の概要

  • 製品名Anti-EDAR antibody
    EDAR 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to EDAR
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region of Human EDAR

  • ポジティブ・コントロール
    • Placenta lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab76399 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 49 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay, 1:12500.

ターゲット情報

  • 機能Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
  • 組織特異性Detected in fetal kidney, lung, skin and cultured neonatal epidermal keratinocytes. Not detected in lymphoblast and fibroblast cell lines.
  • 関連疾患Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA) [MIM:224900]; also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
    Defects in EDAR are the cause of ectodermal dysplasia type 3 (ED3) [MIM:129490]; also known as ectodermal dysplasia hypohidrotic autosomal dominant or EDA3. ED3 is an autosomal dominant condition characterized by hypotrichosis, abnormal or missing teeth, and hypohidrosis due to the absence of sweat glands.
  • 配列類似性Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • 発生段階Found in craniofacial tissues from embryonic day 42-53. Expressed in fetal skin 11 and 15 weeks after gestation.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Anhidrotic ectodysplasin receptor 1 antibody
    • DL antibody
    • Downless (mouse) homolog antibody
    • Downless homolog antibody
    • Downless mouse homolog of antibody
    • ECTD10A antibody
    • ECTD10B antibody
    • Ectodermal dysplasia receptor antibody
    • Ectodysplasin 1 anhidrotic receptor antibody
    • Ectodysplasin A receptor antibody
    • Ectodysplasin A1 isoform receptor antibody
    • Ectodysplasin-A receptor antibody
    • ED 1R antibody
    • ED 3 antibody
    • ED 5 antibody
    • ED1R antibody
    • ED3 antibody
    • ED5 antibody
    • EDA 1R antibody
    • EDA 3 antibody
    • EDA A1 receptor antibody
    • EDA A1R antibody
    • EDA-A1 receptor antibody
    • EDA1R antibody
    • EDA3 antibody
    • Edar antibody
    • EDAR_HUMAN antibody
    • HRM1 antibody
    • Tumor necrosis factor receptor superfamily member EDAR antibody
    see all

Anti-EDAR antibody 画像

  • Anti-EDAR antibody (ab76399) at 1 µg/ml (in 5% skim milk / PBS buffer) + Placenta lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 49 kDa

Anti-EDAR antibody (ab76399) 使用論文

ab76399 has not yet been referenced specifically in any publications.

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