製品の概要

  • 製品名Anti-EDA antibody [MM0254-3T2]
    EDA 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MM0254-3T2] to EDA
  • 特異性ab89401 is able to detect Human EDA Isoform A2, as well Isoform A1.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant Human EDA Isoform A2 extracellular domain.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab89401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 42 kDa.

ターゲット情報

  • 機能Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR.
  • 組織特異性Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord.
  • 関連疾患Defects in EDA are the cause of ectodermal dysplasia type 1 (ED1) [MIM:305100]; also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias.
    Defects in EDA are the cause of tooth agenesis selective X-linked type 1 (STHAGX1) [MIM:313500]. A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth).
  • 配列類似性Belongs to the tumor necrosis factor family.
    Contains 1 collagen-like domain.
  • 翻訳後修飾N-glycosylated.
    Processing by furin produces a secreted form.
  • 細胞内局在Secreted and Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ECTD1 antibody
    • Ectodermal dysplasia 1, anhidrotic antibody
    • Ectodermal dysplasia protein antibody
    • Ectodermal dysplasia, anhidrotic (hypohydrotic) antibody
    • Ectodysplasin A antibody
    • Ectodysplasin A, membrane form antibody
    • Ectodysplasin A, secreted form antibody
    • ECTODYSPLASIN A1 ISOFORM antibody
    • ECTODYSPLASIN A2 ISOFORM antibody
    • ECTODYSPLASIN antibody
    • Ectodysplasin-A antibody
    • ED1 A1 antibody
    • ED1 A2 antibody
    • ED1 antibody
    • ED1 GENE antibody
    • Eda A1 antibody
    • Eda A2 antibody
    • eda antibody
    • EDA protein antibody
    • EDA protein homolog antibody
    • EDA_HUMAN antibody
    • EDA1 antibody
    • EDA1 GENE antibody
    • EDA2 antibody
    • HED antibody
    • HED1 antibody
    • ODT1 antibody
    • Oligodontia 1 antibody
    • secreted form antibody
    • STHAGX1 antibody
    • Ta antibody
    • Tabby antibody
    • Tabby protein antibody
    • X linked anhidroitic ectodermal dysplasia protein antibody
    • XHED antibody
    • XLHED antibody
    see all

Anti-EDA antibody [MM0254-3T2] (ab89401) 使用論文

ab89401 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"