製品の概要

  • 製品名Anti-EBV LMP2A antibody [15F9]
    EBV LMP2A 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [15F9] to EBV LMP2A
  • 特異性ab59028 recognises LMP2A and does not cross react with LMP2B.
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    Reacts with Epstein Barr Virus.
  • 免疫原

    Bacterial TrpE-LMP2A fusion protein

  • ポジティブ・コントロール
    • Hodgkin’s Disease

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 精製度Protein G purified
  • 特記事項(精製)Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
  • ポリ/モノモノクローナル
  • クローン名15F9
  • ミエローマP3x63-Ag8.653
  • アイソタイプIgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab59028 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/1000.
IHC-P Use at an assay dependent dilution.

ターゲット情報

  • 関連性Epstein Barr virus (EBV) is a member of the herpesvirus family and one of the most common human viruses. Most people become infected with EBV during their lives. Primary infections usually results in infectious mononucleosis (glandular fever) but the virus can also lay dormant in B lymphocytes and when reactivated become associated with more serious disease such as Burkitt's lymphoma, nasopharyngeal carcinoma and Hodgkin's disease. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.
  • 別名
    • EBV latent membrane protein 2A antibody
    • Epstein Barr virus antibody
    • HHV4 antibody
    • Human Herpesvirus 4 antibody
    • Latent membrane protein 2 antibody
    • LMP2 antibody
    • Terminal protein antibody
    see all

Anti-EBV LMP2A antibody [15F9] (ab59028) 使用論文

This product has been referenced in:
  • Cohen M  et al. Epstein-Barr virus presence in pediatric diffuse large B-cell lymphoma reveals a particular association and latency patterns: analysis of viral role in tumor microenvironment. Int J Cancer 132:1572-80 (2013). Read more (PubMed: 22987474) »
  • Vincent-Bugnas S  et al. EBV infection is common in gingival epithelial cells of the periodontium and worsens during chronic periodontitis. PLoS One 8:e80336 (2013). IHC-P . Read more (PubMed: 24367478) »

See all 3 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab59028.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"