Anti-EBV Latent Membrane Protein 1 抗体 [CS 1-4] (ab78113)
Key features and details
- Mouse monoclonal [CS 1-4] to EBV Latent Membrane Protein 1
- Suitable for: WB, IP, IHC-P, IHC-Fr
- Isotype: IgG1
製品の概要
-
製品名
Anti-EBV Latent Membrane Protein 1 antibody [CS 1-4]
EBV Latent Membrane Protein 1 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [CS 1-4] to EBV Latent Membrane Protein 1 -
由来種
Mouse -
特異性
This antibody is specific for Epstein-Barr virus infected cells expressing the latent membrane protein (LMP). This is in fact four pooled antibodies which collectively detect LMP's encoded by each of 20 geographically distinct EBV isolates. -
アプリケーション
適用あり: WB, IP, IHC-P, IHC-Frmore details -
種交差性
交差種: Epstein-Barr virus -
免疫原
Fusion protein corresponding to EBV Latent Membrane Protein 1.
Database link: P03230 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Preservative: 0.02% Sodium azide
Constituent: 99.98% PBS -
Concentration information loading...
-
精製度
Protein A purified -
特記事項(精製)
Affinity chromatography -
ポリ/モノ
モノクローナル -
クローン名
CS 1-4 -
ミエローマ
x63-Ag8.653 -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab78113の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB | (2) |
Use at an assay dependent concentration. Predicted molecular weight: 42 kDa.
|
IP |
Use at an assay dependent concentration.
|
|
IHC-P |
Use at an assay dependent concentration.
|
|
IHC-Fr |
Use at an assay dependent concentration.
|
特記事項 |
---|
WB
Use at an assay dependent concentration. Predicted molecular weight: 42 kDa. |
IP
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
ターゲット情報
-
関連性
EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases, including infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. LMP1 can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells. -
参照データベース
- Entrez Gene: 3783750 Epstein-Barr virus
- SwissProt: P0C741 Epstein-Barr virus
-
別名
- BNLF1 antibody
- EBV antibody
- Epstein Barr virus antibody
see all
プロトコール
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (38)
ab78113 は 38 報の論文で使用されています。
- Sidorov S et al. CD4 + T cells are found within endemic Burkitt lymphoma and modulate Burkitt lymphoma precursor cell viability and expression of pathogenically relevant Epstein-Barr virus genes. Cancer Immunol Immunother 71:1371-1392 (2022). PubMed: 34668039
- Zhu N et al. Epstein-Barr Virus LMP1-Activated mTORC1 and mTORC2 Coordinately Promote Nasopharyngeal Cancer Stem Cell Properties. J Virol 96:e0194121 (2022). PubMed: 35019715
- Zvejniece L et al. Expression of the Chemokine Receptor CCR1 in Burkitt Lymphoma Cell Lines Is Linked to the CD10-Negative Cell Phenotype and Co-Expression of the EBV Latent Genes EBNA2, LMP1, and LMP2. Int J Mol Sci 23:N/A (2022). PubMed: 35408790
- Caruso LB et al. The nuclear lamina binds the EBV genome during latency and regulates viral gene expression. PLoS Pathog 18:e1010400 (2022). PubMed: 35421198
- Singh DR et al. Type 1 and Type 2 Epstein-Barr viruses induce proliferation, and inhibit differentiation, in infected telomerase-immortalized normal oral keratinocytes. PLoS Pathog 18:e1010868 (2022). PubMed: 36190982