製品の概要

  • 製品名
    Anti-EB2 antibody [K52]
  • 製品の詳細
    Rat monoclonal [K52] to EB2
  • 特異性
    This antibody is specific for EB2 proteins.
  • アプリケーション
    適用あり: WB, ELISA, IP, ICC/IFmore details
  • 種交差性
    交差種: Mouse, Hamster, Human
  • 免疫原

    Recombinant full length EB2 protein (Human)

  • ポジティブ・コントロール
    • CHO cell lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab45767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 36 kDa.
ELISA 1/2000 - 1/5000.
IP Use at an assay dependent dilution.
ICC/IF Use at an assay dependent dilution.

ターゲット情報

  • 機能
    May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
  • 組織特異性
    Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.
  • 配列類似性
    Belongs to the MAPRE family.
    Contains 1 CH (calponin-homology) domain.
    Contains 1 EB1 C-terminal domain.
  • ドメイン
    Composed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
  • 細胞内局在
    Cytoplasm > cytoskeleton. Associated with the microtubule network. Accumulates at the plus end of microtubules.
  • Information by UniProt
  • 参照データベース
  • 別名
    • APC binding protein EB1 antibody
    • APC binding protein EB2 antibody
    • APC-binding protein EB2 antibody
    • EB1 antibody
    • EB2 antibody
    • End binding protein 2 antibody
    • End-binding protein 2 antibody
    • H.sapiens mRNA for novel T cell activation protein antibody
    • MAPRE2 antibody
    • MARE2_HUMAN antibody
    • Microtubule associated protein RP/EB family member 2 antibody
    • Microtubule-associated protein RP/EB family member 2 antibody
    • RP1 antibody
    • T cell activation protein EB1 family antibody
    see all

画像

  • Immunofluorescence staining of EB2 in CHO cells transfected with EB2 gene expression constructs.

参考文献

This product has been referenced in:
  • Asanov A  et al. A relay mechanism between EB1 and APC facilitate STIM1 puncta assembly at endoplasmic reticulum-plasma membrane junctions. Cell Calcium 54:246-56 (2013). Read more (PubMed: 23871111) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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