Anti-E1 Ubiquitin Activating Enzyme 抗体 (ab123346)

製品の概要

  • 製品名
    Anti-E1 Ubiquitin Activating Enzyme antibody
    E1 Ubiquitin Activating Enzyme 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to E1 Ubiquitin Activating Enzyme
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 1-30 of Human E1 Ubiquitin Activating Enzyme (NP_003325.2, NP_695012.1).

  • ポジティブ・コントロール
    • K562 cell line lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab123346 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 118 kDa.

ターゲット情報

  • 機能
    Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.
  • パスウェイ
    Protein modification; protein ubiquitination.
  • 関連疾患
    Defects in UBA1 are the cause of spinal muscular atrophy X-linked type 2 (SMAX2) [MIM:301830]; also known as X-linked lethal infantile spinal muscular atrophy, distal X-linked arthrogryposis multiplex congenita or X-linked arthrogryposis type 1 (AMCX1). Spinal muscular atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAX2 is a lethal infantile form presenting with hypotonia, areflexia, and multiple congenital contractures.
  • 配列類似性
    Belongs to the ubiquitin-activating E1 family.
  • 翻訳後修飾
    ISGylated.
  • Information by UniProt
  • 参照データベース
  • 別名
    • A1S9 antibody
    • A1S9 protein antibody
    • A1S9T and BN75 temperature sensitivity complementing antibody
    • A1S9T antibody
    • A1ST antibody
    • AMCX1 antibody
    • CFAP124 antibody
    • CTD-2522E6.1 antibody
    • GXP 1 antibody
    • GXP1 antibody
    • MGC4781 antibody
    • POC20 antibody
    • POC20 centriolar protein homolog antibody
    • Protein A1S9 antibody
    • SMAX2 antibody
    • Uba1 antibody
    • UBA1, ubiquitin-activating enzyme E1 homolog A antibody
    • UBA1_HUMAN antibody
    • UBA1A antibody
    • UBE 1 antibody
    • UBE 1X antibody
    • UBE1 antibody
    • UBE1X antibody
    • Ubiquitin activating enzyme E1 antibody
    • Ubiquitin-activating enzyme E1 antibody
    • Ubiquitin-like modifier-activating enzyme 1 antibody
    see all

画像

  • Anti-E1 Ubiquitin Activating Enzyme antibody (ab123346) at 1/100 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 118 kDa

プロトコール

参考文献

ab123346 has not yet been referenced specifically in any publications.

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