製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to DYX1C1
  • 特異性
    ab81986 is expected to recognize three reported isoforms (NP_570722.2, NP_001028731.1 and NP_001028732.1).
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Dog, Chimpanzee, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide:

    PLQVSDYSWQQTKT-C

    , corresponding to N terminal amino acids 2-15 of human DYX1C1 (NP_570722.2; NP_001028731.1; NP_001028732.1).

  • ポジティブ・コントロール
    • Human brain (cerebral cortex and frontal cortex) lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab81986 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報
    Peptide ELISA: Antibody detection limit dilution 1/32000.
    WB: Use at a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 48 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.
    • 組織特異性
      Expressed in several tissues, including brain, lung, kidney and testis. In brain localizes to a fraction of cortical neurons and white matter glial cells.
    • 関連疾患
      Defects in DYX1C1 may be a cause of susceptibility to dyslexia type 1 (DYX1) [MIM:127700]. A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability. Note=A chromosomal aberration involving DYX1C1 has been found in a family affected by dyslexia. Translocation t(2;15)(q11;q21).
    • 配列類似性
      Contains 1 CS domain.
      Contains 3 TPR repeats.
    • 細胞内局在
      Nucleus. Cytoplasm.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Dyslexia susceptibility 1 candidate 1 antibody
      • Dyslexia susceptibility 1 candidate gene 1 protein antibody
      • DYX1 antibody
      • DYX1C1 antibody
      • DYXC1 antibody
      • DYXC1_HUMAN antibody
      • EKN1 antibody
      • FLJ37882 antibody
      • MGC70618 antibody
      • RD antibody
      see all

    画像

    • Anti-DYX1C1 antibody (ab81986) at 0.5 µg/ml + human brain (frontal cortex) lysate (in RIPA buffer) at 35 µg
      Developed using the ECL technique

      Predicted band size : 48 kDa
      Observed band size : 48 kDa
      Additional bands at : 40 kDa. We are unsure as to the identity of these extra bands.

    プロトコール

    参考文献

    ab81986 has not yet been referenced specifically in any publications.

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