製品の概要

  • 製品名Anti-Dystrobrevin alpha antibody
    Dystrobrevin alpha 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Dystrobrevin alpha
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 691-721 of Human Dystrobrevin alpha (NP_001381.2, NP_116760.2, NP_116763.1, NP_001382.2, NP_001383.2, NP_116761.2, NP_116757.2 and NP_116762.2).

  • ポジティブ・コントロール
    • Mouse heart tissue lysates

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab112949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 84 kDa.

ターゲット情報

  • 機能May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
  • 組織特異性Highly expressed in brain, skeletal and cardiac muscles, and expressed at lower levels in lung, liver and pancreas. Isoform 2 is not expressed in cardiac muscle. Isoform 7 and isoform 8 are only expressed in muscle.
  • 関連疾患Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:604169]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricule with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.
  • 配列類似性Belongs to the dystrophin family. Dystrobrevin subfamily.
    Contains 1 ZZ-type zinc finger.
  • ドメインThe coiled coil domain mediates the interaction with dystrophin and utrophin.
  • 翻訳後修飾Phosphorylation of DTN-1 on tyrosine kinase substrate domain present in the C-terminus.
  • 細胞内局在Cytoplasm. Cell junction > synapse. Cell membrane. In peripheral nerves, co-localizes with MAGEE1 in the Schwann cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Alpha-dystrobrevin antibody
    • D18S892E antibody
    • DRP3 antibody
    • DTN antibody
    • DTN-A antibody
    • DTNA antibody
    • DTNA_HUMAN antibody
    • Dystrobrevin alpha antibody
    • Dystrophin related protein 3 antibody
    • Dystrophin-related protein 3 antibody
    • FLJ96209 antibody
    • LVNC1 antibody
    • OTTHUMP00000163151 antibody
    • OTTHUMP00000163152 antibody
    • OTTHUMP00000163153 antibody
    • OTTHUMP00000163154 antibody
    • OTTHUMP00000163155 antibody
    see all

Anti-Dystrobrevin alpha antibody 画像

  • Anti-Dystrobrevin alpha antibody (ab112949) at 1/100 dilution + Mouse heart tissue lysates at 35 µg

    Predicted band size : 84 kDa

Anti-Dystrobrevin alpha antibody (ab112949) 使用論文

ab112949 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"