製品の概要

  • 製品名
    Anti-Dystonin antibody
  • 製品の詳細
    Mouse monoclonal to Dystonin
  • アプリケーション
    適用あり: Sandwich ELISA, ICC/IF, WB, IHC-Frmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Recombinant fragment: EDKLILAGNA LQSDSKRLES GVQFQNEAEI AGYILECENL LRQHVIDVQI LIDGKYYQAD QLVQRVAKLR DEIMALRNEC SSVYSKGRIL TTEQTKLMIS , corresponding to amino acids 401-501 of Human Dystonin

  • 特記事項

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause. 

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 精製度
    Protein G purified
  • ポリ/モノ
    モノクローナル
  • アイソタイプ
    IgG1
  • 軽鎖の種類
    kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab55654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Sandwich ELISA Use at an assay dependent concentration.
ICC/IF Use a concentration of 10 µg/ml.
WB Use a concentration of 1 - 5 µg/ml.
IHC-Fr Use at an assay dependent concentration. PubMed: 18638474

ターゲット情報

  • 関連性
    Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Isoform 3: plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity. Isoform 6: required for bundling actin filaments around the nucleus By similarity. Isoform 7: regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
  • 細胞内局在
    Cytoplasm › cytoskeleton.
  • 参照データベース
  • 別名
    • 230 kDa bullous pemphigoid antigen antibody
    • 230/240 kDa bullous pemphigoid antigen antibody
    • BP230 antibody
    • BP240 antibody
    • BPA antibody
    • BPAG1 antibody
    • Bullous pemphigoid antigen 1 antibody
    • Bullous pemphigoid antigen antibody
    • DMH antibody
    • DST antibody
    • DT antibody
    • Dystonia musculorum protein antibody
    • Hemidesmosomal plaque protein antibody
    • KIAA0728 antibody
    see all

画像

  • Immunofluorescent staining of HeLa cells using ab55654 at 10 μg/mL.

  • Western blot against tagged recombinant protein immunogen using ab55654 Dystonin antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

参考文献

This product has been referenced in:
  • Young KG & Kothary R Dystonin/Bpag1 is a necessary endoplasmic reticulum/nuclear envelope protein in sensory neurons. Exp Cell Res 314:2750-61 (2008). IHC-Fr ; Mouse . Read more (PubMed: 18638474) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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